Seroatlas · Human Serome Atlas

CPSF4L

Putative cleavage and polyadenylation specificity factor subunit 4-like protein

Also known as: CPS4L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMK7
Gene: CPSF4L
Ensembl: ENSG00000187959
Chromosome: 17
Canonical length: 179 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable RNA binding activity and zinc ion binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>A6NMK7|CPSF4L
     1  MQEVIAGLER FTFAFEKDVE MQKGTGLLPF QGMDKSASAV CNFFTKGLCE KGKLCPFRHD
    61  RGEKMVVCKH WLRGLCKKGD HCKFLHQYDL TRMPECYFYS KFGDCSNKEC SFLHVKPAFK
   121  SQDCPWYDQG FCKDGPLCKY RHVPRIMCLN YLVGFCPEGP KCQFAQKIRE FKLLPGSKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPSF4L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

ovary: 0.6 nTPM
retina: 0.5 nTPM
salivary gland: 0.5 nTPM
breast: 0.4 nTPM
pancreas: 0.4 nTPM
testis: 0.4 nTPM

Single-cell type

oocytes: 32 nCPM
salivary basal cells: 17 nCPM
paneth cells: 7.7 nCPM
pituicytes/fscs: 6.6 nCPM
hepatic stellate cells: 6.5 nCPM
müller glia: 6.3 nCPM

Immune cell

eosinophil: 0.3 nTPM
neutrophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 2.9 nTPM
medulla oblongata: 1.7 nTPM
cerebral cortex: 1.3 nTPM
midbrain: 1.3 nTPM
white matter: 1.3 nTPM
hippocampal formation: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

mRNA cleavage and polyadenylation specificity factor complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPSF4L as an antibody target. Whether an autoantibody or antibody against CPSF4L could matter depends on whether native CPSF4L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPSF4L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPSF4L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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