Seroatlas · Human Serome Atlas

CPQ

Carboxypeptidase Q

Also known as: CBPQ_HUMAN, LDP, PGCP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y646
Gene: CPQ
Ensembl: ENSG00000104324
Chromosome: 8
Canonical length: 472 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus,Vesicles
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein may catalyze the cleavage of dipeptides with unsubstituted terminals into amino acids. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>Q9Y646|CPQ
     1  MKFLIFAFFG GVHLLSLCSG KAICKNGISK RTFEEIKEEI ASCGDVAKAI INLAVYGKAQ
    61  NRSYERLALL VDTVGPRLSG SKNLEKAIQI MYQNLQQDGL EKVHLEPVRI PHWERGEESA
   121  VMLEPRIHKI AILGLGSSIG TPPEGITAEV LVVTSFDELQ RRASEARGKI VVYNQPYINY
   181  SRTVQYRTQG AVEAAKVGAL ASLIRSVASF SIYSPHTGIQ EYQDGVPKIP TACITVEDAE
   241  MMSRMASHGI KIVIQLKMGA KTYPDTDSFN TVAEITGSKY PEQVVLVSGH LDSWDVGQGA
   301  MDDGGGAFIS WEALSLIKDL GLRPKRTLRL VLWTAEEQGG VGAFQYYQLH KVNISNYSLV
   361  MESDAGTFLP TGLQFTGSEK ARAIMEEVMS LLQPLNITQV LSHGEGTDIN FWIQAGVPGA
   421  SLLDDLYKYF FFHHSHGDTM TVMDPKQMNV AAAVWAVVSY VVADMEEMLP RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 212 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 212 nTPM
ovary: 100 nTPM
blood vessel: 80 nTPM
kidney: 75 nTPM
cervix: 71 nTPM
liver: 65 nTPM

Single-cell type

neutrophils: 2,620 nCPM
fibro-adipogenic progenitors: 619 nCPM
bergmann glia: 408 nCPM
oligodendrocytes: 378 nCPM
renal collecting duct intercalated cells: 367 nCPM
neutrophil progenitors: 326 nCPM

Immune cell

neutrophil: 252 nTPM
classical monocyte: 72 nTPM
myeloid DC: 52 nTPM
intermediate monocyte: 50 nTPM
non-classical monocyte: 48 nTPM
eosinophil: 45 nTPM

Brain region

white matter: 78 nTPM
basal ganglia: 69 nTPM
medulla oblongata: 68 nTPM
thalamus: 63 nTPM
cerebellum: 58 nTPM
pons: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPQ as an antibody target. Whether an autoantibody or antibody against CPQ could matter depends on whether native CPQ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPQ is annotated as secreted, so native CPQ circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CPQ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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