Seroatlas · Human Serome Atlas

CPO

Carboxypeptidase O

Also known as: CBPO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVL8
Gene: CPO
Ensembl: ENSG00000144410
Chromosome: 2
Canonical length: 374 aa
Protein class: Enzymes, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q8IVL8|CPO
     1  MKPLLETLYL LGMLVPGGLG YDRSLAQHRQ EIVDKSVSPW SLETYSYNIY HPMGEIYEWM
    61  REISEKYKEV VTQHFLGVTY ETHPMYYLKI SQPSGNPKKI IWMDCGIHAR EWIAPAFCQW
   121  FVKEILQNHK DNSSIRKLLR NLDFYVLPVL NIDGYIYTWT TDRLWRKSRS PHNNGTCFGT
   181  DLNRNFNASW CSIGASRNCQ DQTFCGTGPV SEPETKAVAS FIESKKDDIL CFLTMHSYGQ
   241  LILTPYGYTK NKSSNHPEMI QVGQKAANAL KAKYGTNYRV GSSADILYAS SGSSRDWARD
   301  IGIPFSYTFE LRDSGTYGFV LPEAQIQPTC EETMEAVLSV LDDVYAKHWH SDSAGRVTSA
   361  TMLLGLLVSC MSLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

small intestine: 105 nTPM
epididymis: 7.1 nTPM
choroid plexus: 1.8 nTPM
basal ganglia: 1.6 nTPM
kidney: 1.2 nTPM
pituitary gland: 1.2 nTPM

Single-cell type

enterocytes: 393 nCPM
paneth cells: 19 nCPM
podocytes: 15 nCPM
pituicytes/fscs: 14 nCPM
brain inhibitory neurons: 14 nCPM
choroid plexus epithelial cells: 14 nCPM

Immune cell

basophil: 12 nTPM
eosinophil: 0.4 nTPM
naive CD4 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 6.3 nTPM
thalamus: 4.9 nTPM
basal ganglia: 4.7 nTPM
cerebral cortex: 4.7 nTPM
pons: 4.7 nTPM
hypothalamus: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase M14, carboxypeptidase A
Zinc carboxypeptidases, zinc-binding region 1
Zinc carboxypeptidase
Carboxypeptidase O

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPO as an antibody target. Whether an autoantibody or antibody against CPO could matter depends on whether native CPO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPO is annotated at the cell surface, where native CPO is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...