Seroatlas · Human Serome Atlas

CPLX4

Complexin-4

Also known as: CPLX4_HUMAN, CPX-IV

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7G2
Gene
CPLX4
Ensembl
ENSG00000166569
Chromosome
18
Canonical length
160 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene likely encodes a member of the complexin family. The encoded protein may be involved in synaptic vesicle exocytosis. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q7Z7G2|CPLX4
     1  MAFLMKSMIS NQVKNLGFGG GSEENKEEGG ASDPAAAQGM TREEYEEYQK QMIEEKMERD
    61  AAFTQKKAER ACLRVHLREK YRLPKSEMDE NQIQMAGDDV DLPEDLRKMV DEDQEEEEDK
   121  DSILGQIQNL QNMDLDTIKE KAQATFTEIK QTAEQKCSVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPLX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
292 nTPM

Expression across tissuesHPA

Tissue

  • retina: 292 nTPM
  • choroid plexus: 3.2 nTPM
  • cerebellum: 1.3 nTPM
  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • rod photoreceptor cells: 283 nCPM
  • cone photoreceptor cells: 248 nCPM
  • retinal bipolar cells: 92 nCPM
  • müller glia: 15 nCPM
  • retinal horizontal cells: 10 nCPM
  • retinal pigment epithelial cells: 8.5 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 2.7 nTPM
  • hypothalamus: 1.8 nTPM
  • choroid plexus: 1.7 nTPM
  • cerebral cortex: 0.9 nTPM
  • white matter: 0.7 nTPM
  • amygdala: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.71
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
0.26
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPLX4 as an antibody target. Whether an autoantibody or antibody against CPLX4 could matter depends on whether native CPLX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPLX4 is annotated at the cell surface, where native CPLX4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPLX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPLX4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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