Seroatlas · Human Serome Atlas

CPLX2

Complexin-2

Also known as: CPLX2_HUMAN, CPX-2, DKFZp547D155

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PUV4
Gene: CPLX2
Ensembl: ENSG00000145920
Chromosome: 5
Canonical length: 134 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q6PUV4|CPLX2
     1  MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA KHARMEAERE
    61  KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA IPAGCGDEEE EEEESILDTV
   121  LKYLPGPLQD MFKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPLX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 462 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 462 nTPM
cerebellum: 449 nTPM
amygdala: 434 nTPM
cerebral cortex: 335 nTPM
midbrain: 184 nTPM
basal ganglia: 181 nTPM

Single-cell type

late spermatids: 131 nCPM
retinal amacrine cells: 126 nCPM
pancreatic islet cells: 123 nCPM
brain excitatory neurons: 109 nCPM
epididymal principal cells: 96 nCPM
corticotrophs: 83 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 793 nTPM
cerebral cortex: 752 nTPM
amygdala: 646 nTPM
white matter: 469 nTPM
midbrain: 363 nTPM
cerebellum: 307 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.53
gnomAD missense Z: 1.32
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPLX2 as an antibody target. Whether an autoantibody or antibody against CPLX2 could matter depends on whether native CPLX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPLX2 is annotated at the cell surface, where native CPLX2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPLX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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