Seroatlas · Human Serome Atlas

CPHXL2

Cytoplasmic polyadenylated homeobox-like protein 2

Also known as: CPHL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PPK0
Gene
CPHXL2
Ensembl
ENSG00000284484
Chromosome
16
Canonical length
400 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>A0A1W2PPK0|CPHXL2
     1  MSSQAFPAEE DHHNEERQTK KKRKTKHRHK FSEELLQELK EIFGENGYPD FTTRKTLANK
    61  FDCPVNVINN WFQNNRARLP PEERQRIFLT WKKHDFPVQA CPFLSLQETQ AAASNYATEQ
   121  SFSCAKRALM RRPGCSLLEK QRIACQQMGY NCFSLENQET PSQQVGSMCS SLEKQGIPSQ
   181  QVGSQCSYLV AGTEKHPGYA LEYGGDTGSE HSTAYRFLSY NSAECLHPPP SSVPYFHGER
   241  TETRESQHAS PFLLDYAQGA YGVKKDHCLC SFCLSLLQEQ QQNDWQYHPQ QHQQPQNYSE
   301  GMMLQEQLPM DSGPWDLEKQ WPSAQSQLQS QLPQNNGKPL CSQLQHVPPQ IAANSPLLPL
   361  GQDMQVGASS NSGLKCSSFR LRGLHGPATG TQGCSFAKYC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPHXL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • retina: 0.1 nTPM
  • skin: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • cardiomyocytes: 31 nCPM
  • adipocytes: 19 nCPM
  • epicardial cells: 14 nCPM
  • myonuclei: 12 nCPM
  • fibro-adipogenic progenitors: 12 nCPM
  • rod photoreceptor cells: 7.1 nCPM

Immune cell

  • naive B-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • white matter: 4.6 nTPM
  • cerebellum: 4 nTPM
  • basal ganglia: 3.6 nTPM
  • cerebral cortex: 3.6 nTPM
  • medulla oblongata: 3.5 nTPM
  • midbrain: 3.3 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPHXL2 as an antibody target. Whether an autoantibody or antibody against CPHXL2 could matter depends on whether native CPHXL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPHXL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPHXL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPHXL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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