Seroatlas · Human Serome Atlas

CPHXL

Cytoplasmic polyadenylated homeobox-like protein

Also known as: CPHXL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PPM1
Gene
CPHXL
Ensembl
ENSG00000283755
Chromosome
16
Canonical length
405 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

405 residues, UniProt reviewed canonical sequence.

>A0A1W2PPM1|CPHXL
     1  MNLDGTSGGF PAEEDHHNEE RQTKNKRKTK HRHKFSEELL QELKEIFGEN CYPDYTTRKT
    61  LAIKFDCPVN VIDNWFQNKR ARLPPAERRR IFVLQKKHDF PVQAHSFLSC QETQAAAHNY
   121  ATKQSLSGAQ RALMRRAGCS HLEKQWIPSQ EMGYNCFSLE NQETPSQQVG PQCSYLEKPG
   181  IPSQQVGSQC SYLEKLGIPS QQVASQSSYL VTGTEKHPGC AMGYGGDTGS GHSGSGHSTA
   241  YHFLSYNSAE CLHPPPSSVP YFHGERTETK ESQHASPFLL DYAQGAYGVK KDHCLCSFCL
   301  SLLGQQQQND WQYHLQQHQQ PQNYLEGMML QEQLPMDSGP WDLGKQWSSA QSQLQSQLPQ
   361  NNGKPLCSQL QHMSLQIAAD SPLLPLGQDM QERASEQPRT QMQQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPHXL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.5 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • retinal ganglion cells: 19 nCPM
  • retinal horizontal cells: 14 nCPM
  • epicardial cells: 14 nCPM
  • cardiomyocytes: 10 nCPM
  • fibro-adipogenic progenitors: 7.4 nCPM
  • myonuclei: 6.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.8 nTPM
  • medulla oblongata: 1.6 nTPM
  • white matter: 1.5 nTPM
  • basal ganglia: 1.4 nTPM
  • hippocampal formation: 1.4 nTPM
  • pons: 1.4 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPHXL as an antibody target. Whether an autoantibody or antibody against CPHXL could matter depends on whether native CPHXL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPHXL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPHXL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPHXL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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