Seroatlas · Human Serome Atlas

CPA5

Carboxypeptidase A5

Also known as: CBPA5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXQ8
Gene: CPA5
Ensembl: ENSG00000158525
Chromosome: 7
Canonical length: 436 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q8WXQ8|CPA5
     1  MQGTPGGGTR PGPSPVDRRT LLVFSFILAA ALGQMNFTGD QVLRVLAKDE KQLSLLGDLE
    61  GLKPQKVDFW RGPARPSLPV DMRVPFSELK DIKAYLESHG LAYSIMIKDI QVLLDEERQA
   121  MAKSRRLERS TNSFSYSSYH TLEEIYSWID NFVMEHSDIV SKIQIGNSFE NQSILVLKFS
   181  TGGSRHPAIW IDTGIHSREW ITHATGIWTA NKIVSDYGKD RVLTDILNAM DIFIELVTNP
   241  DGFAFTHSMN RLWRKNKSIR PGIFCIGVDL NRNWKSGFGG NGSNSNPCSE TYHGPSPQSE
   301  PEVAAIVNFI TAHGNFKALI SIHSYSQMLM YPYGRLLEPV SNQRELYDLA KDAVEALYKV
   361  HGIEYIFGSI STTLYVASGI TVDWAYDSGI KYAFSFELRD TGQYGFLLPA TQIIPTAQET
   421  WMALRTIMEH TLNHPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
thymus: 2.1 nTPM
lymph node: 1.8 nTPM
spleen: 1.7 nTPM
pituitary gland: 1.2 nTPM
skin: 0.9 nTPM

Single-cell type

late spermatids: 258 nCPM
early spermatids: 64 nCPM
late primary spermatocytes: 55 nCPM
myosatellite cells: 8 nCPM
syncytiotrophoblasts: 5.7 nCPM
cytotrophoblasts: 4.1 nCPM

Immune cell

T-reg: 57 nTPM
naive CD8 T-cell: 43 nTPM
memory CD4 T-cell: 17 nTPM
memory CD8 T-cell: 8.6 nTPM
total PBMC: 5.8 nTPM
naive CD4 T-cell: 4.2 nTPM

Brain region

hypothalamus: 0.8 nTPM
cerebral cortex: 0.6 nTPM
pons: 0.6 nTPM
white matter: 0.6 nTPM
midbrain: 0.5 nTPM
medulla oblongata: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 0.59
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPA5 as an antibody target. Whether an autoantibody or antibody against CPA5 could matter depends on whether native CPA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPA5 is annotated as secreted, so native CPA5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CPA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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