Seroatlas · Human Serome Atlas

COX8C

Cytochrome c oxidase subunit 8C, mitochondrial

Also known as: COX8-3, COX8C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z4L0
Gene
COX8C
Ensembl
ENSG00000187581
Chromosome
14
Canonical length
72 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

72 residues, UniProt reviewed canonical sequence.

>Q7Z4L0|COX8C
     1  MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV FFTTFLTPAA
    61  YVLGNLKQFR RN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX8C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • testis: 72 nTPM
  • heart muscle: 0.3 nTPM
  • cerebellum: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • pituitary gland: 0.2 nTPM
  • skeletal muscle: 0.2 nTPM

Single-cell type

  • late spermatids: 866 nCPM
  • early spermatids: 328 nCPM
  • late primary spermatocytes: 192 nCPM
  • early primary spermatocytes: 175 nCPM
  • oocytes: 97 nCPM
  • differentiating spermatogonia: 50 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 4.1 nTPM
  • cerebellum: 2.4 nTPM
  • medulla oblongata: 2.4 nTPM
  • basal ganglia: 2.2 nTPM
  • pons: 2.2 nTPM
  • cerebral cortex: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0.11
gnomAD missense Z
0.15
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COX8C as an antibody target. Whether an autoantibody or antibody against COX8C could matter depends on whether native COX8C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COX8C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COX8C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COX8C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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