COX7C

Protein identityUniProt · HPA

UniProt accession

P15954

Gene

COX7C

Ensembl

ENSG00000127184

Chromosome

5

Canonical length

63 aa

Protein class

Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

63 residues, UniProt reviewed canonical sequence.

>P15954|COX7C
     1  MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWSLLAK MCLYFGSAFA TPFLVVRHQL
    61  LKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX7C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

2,234 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.14

gnomAD pLI

0.56

gnomAD missense Z

0.33

DepMap mean gene effect

-0.47

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular respiration
• generation of precursor metabolites and energy
• mitochondrial electron transport, cytochrome c to oxygen

Cellular components

• mitochondrial inner membrane
• mitochondrial membrane
• mitochondrion
• respiratory chain complex IV

Protein domainsUniProt · Pfam · InterPro

• Cytochrome c oxidase subunit VIIc
• Cytochrome c oxidase subunit VIIc superfamily
• Cytochrome c oxidase subunit VIIc

KeywordsUniProt

• Acetylation
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Transit peptide
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of COX7C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RAB5IF
• MT-CO2