Seroatlas · Human Serome Atlas

COX7B2

Cytochrome c oxidase subunit 7B2, mitochondrial

Also known as: CX7B2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TF08
Gene
COX7B2
Ensembl
ENSG00000170516
Chromosome
4
Canonical length
81 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to act upstream of or within spermatogenesis. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

81 residues, UniProt reviewed canonical sequence.

>Q8TF08|COX7B2
     1  MMFPLARNAL SSLKIQSILQ SMARHSHVKH SPDFHDKYGN AVLASGTAFC VATWVFTATQ
    61  IGIEWNLSPV GRVTPKEWKH Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX7B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
80 nTPM

Expression across tissuesHPA

Tissue

  • testis: 80 nTPM
  • placenta: 1.1 nTPM
  • adipose tissue: 0.1 nTPM
  • skin: 0.1 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • late primary spermatocytes: 1,075 nCPM
  • early spermatids: 425 nCPM
  • late spermatids: 234 nCPM
  • early primary spermatocytes: 222 nCPM
  • undifferentiated spermatogonia: 77 nCPM
  • differentiating spermatogonia: 70 nCPM

Immune cell

  • neutrophil: 0.8 nTPM
  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • medulla oblongata: 1.7 nTPM
  • white matter: 1.6 nTPM
  • cerebral cortex: 1.5 nTPM
  • thalamus: 1.4 nTPM
  • hippocampal formation: 1.3 nTPM
  • pons: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.77
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COX7B2 as an antibody target. Whether an autoantibody or antibody against COX7B2 could matter depends on whether native COX7B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COX7B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COX7B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COX7B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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