Seroatlas · Human Serome Atlas

COX7A2L

Cytochrome c oxidase subunit 7A2-like, mitochondrial

Also known as: CO72L_HUMAN, COX7AR, COX7RP, EB1, SCAF1, SCAFI, SIG81

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14548
Gene
COX7A2L
Ensembl
ENSG00000115944
Chromosome
2
Canonical length
114 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli,Mitochondria

OverviewNCBI Gene

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>O14548|COX7A2L
     1  MYYKFSGFTQ KLAGAWASEA YSPQGLKPVV STEAPPIIFA TPTKLTSDST VYDYAGKNKV
    61  PELQKFFQKA DGVPVYLKRG LPDQMLYRTT MALTVGGTIY CLIALYMASQ PKNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX7A2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
78 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 78 nTPM
  • parathyroid gland: 68 nTPM
  • adrenal gland: 66 nTPM
  • ovary: 60 nTPM
  • retina: 58 nTPM
  • kidney: 56 nTPM

Single-cell type

  • oocytes: 806 nCPM
  • parietal cells: 735 nCPM
  • syncytiotrophoblasts: 410 nCPM
  • extravillous trophoblasts: 399 nCPM
  • decidual stromal cells: 395 nCPM
  • epididymal clear cells: 365 nCPM

Immune cell

  • total PBMC: 189 nTPM
  • basophil: 104 nTPM
  • plasmacytoid DC: 99 nTPM
  • T-reg: 88 nTPM
  • myeloid DC: 84 nTPM
  • non-classical monocyte: 81 nTPM

Brain region

  • basal ganglia: 37 nTPM
  • hypothalamus: 36 nTPM
  • choroid plexus: 34 nTPM
  • cerebral cortex: 33 nTPM
  • pons: 33 nTPM
  • hippocampal formation: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.9
gnomAD pLI
0
gnomAD missense Z
-0.81
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COX7A2L as an antibody target. Whether an autoantibody or antibody against COX7A2L could matter depends on whether native COX7A2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COX7A2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COX7A2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COX7A2L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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