Seroatlas · Human Serome Atlas

COX7A1

Cytochrome c oxidase subunit 7A1, mitochondrial

Also known as: COX7A, COX7AH, CX7A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P24310
Gene: COX7A1
Ensembl: ENSG00000161281
Chromosome: 19
Canonical length: 79 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>P24310|COX7A1
     1  MQALRVSQAL IRSFSSTARN RFQNRVREKQ KLFQEDNDIP LYLKGGIVDN ILYRVTMTLC
    61  LGGTVYSLYS LGWASFPRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX7A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 6,520 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 6,520 nTPM
tongue: 4,622 nTPM
heart muscle: 4,517 nTPM
blood vessel: 448 nTPM
colon: 283 nTPM
adipose tissue: 272 nTPM

Single-cell type

thymic myoid cells: 1,017 nCPM
vascular smooth muscle cells: 280 nCPM
smooth muscle cells: 278 nCPM
decidual stromal cells: 269 nCPM
peritubular myoid cells: 212 nCPM
breast myoepithelial cells: 173 nCPM

Immune cell

intermediate monocyte: 0.8 nTPM
classical monocyte: 0.6 nTPM
myeloid DC: 0.6 nTPM
neutrophil: 0.4 nTPM
non-classical monocyte: 0.3 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

cerebral cortex: 172 nTPM
white matter: 110 nTPM
hypothalamus: 105 nTPM
thalamus: 73 nTPM
pons: 72 nTPM
amygdala: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COX7A1 as an antibody target. Whether an autoantibody or antibody against COX7A1 could matter depends on whether native COX7A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COX7A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COX7A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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