Seroatlas · Human Serome Atlas

COX6B2

Cytochrome c oxidase subunit 6B2

Also known as: COXVIB2, CT59, CX6B2_HUMAN, FLJ32865

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6YFQ2
Gene
COX6B2
Ensembl
ENSG00000160471
Chromosome
19
Canonical length
88 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in oxidative phosphorylation. Located in mitochondrial crista. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

88 residues, UniProt reviewed canonical sequence.

>Q6YFQ2|COX6B2
     1  MLDVEAQEPP KGKWSTPPFD PRFPSQNQIR NCYQNFLDYH RCLKTRTRRG KSTQPCEYYF
    61  RVYHSLCPIS WVESWNEQIK NGIFAGKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX6B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
87 nTPM

Expression across tissuesHPA

Tissue

  • testis: 87 nTPM
  • colon: 6.3 nTPM
  • rectum: 4.5 nTPM
  • thymus: 3 nTPM
  • skin: 2.4 nTPM
  • tonsil: 1.7 nTPM

Single-cell type

  • late primary spermatocytes: 65 nCPM
  • early primary spermatocytes: 28 nCPM
  • early spermatids: 13 nCPM
  • colonocytes: 7.9 nCPM
  • respiratory deuterosomal cells: 6.2 nCPM
  • medullary thymic epithelial cells: 4.8 nCPM

Immune cell

  • neutrophil: 1.4 nTPM
  • basophil: 0.6 nTPM
  • NK-cell: 0.4 nTPM
  • naive B-cell: 0.3 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • classical monocyte: 0.2 nTPM

Brain region

  • cerebellum: 4.4 nTPM
  • midbrain: 3.7 nTPM
  • cerebral cortex: 3.5 nTPM
  • choroid plexus: 3.5 nTPM
  • pons: 3.5 nTPM
  • white matter: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
gnomAD missense Z
-0.33
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COX6B2 as an antibody target. Whether an autoantibody or antibody against COX6B2 could matter depends on whether native COX6B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COX6B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COX6B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COX6B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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