COX18

Protein identityUniProt · HPA

UniProt accession

Q8N8Q8

Gene

COX18

Ensembl

ENSG00000163626

Chromosome

4

Canonical length

333 aa

Protein class

Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>Q8N8Q8|COX18
     1  MLCRLGGRWL RPLPALQLWA RDLPLAPVPT SGAKRPTLPV WAVAPVSAVH ANGWYEALAA
    61  SSPVRVAEEV LLGVHAATGL PWWGSILLST VALRGAVTLP LAAYQHYILA KVENLQPEIK
   121  TIARHLNQEV AVRANQLGWS KRDARLTYLK NMRRLISELY VRDNCHPFKA TVLVWIQLPM
   181  WIFMSFALRN LSTGAAHSEG FSVQEQLATG GILWFPDLTA PDSTWILPIS VGVINLLIVE
   241  ICALQKIGMS RFQTYITYFV RAMSVLMIPI AATVPSSIVL YWLCSSFVGL SQNLLLRSPG
   301  FRQLCRIPST KSDSETPYKD IFAAFNTKFI SRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

3

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

1.4 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COX18.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 74 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Charcot-marie-tooth disease, axonal, type 2MM

Disease | ImmuneIEDB

Conditions an epitope on COX18 was assayed in.

• glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.7

gnomAD pLI

0

gnomAD missense Z

0.13

DepMap mean gene effect

-0.21

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial respiratory chain complex IV assembly
• protein insertion into mitochondrial inner membrane from matrix
• protein insertion into mitochondrial membrane
• respiratory chain complex IV assembly

Molecular functions

• membrane insertase activity

Cellular components

• mitochondrial inner membrane
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Membrane insertase YidC/ALB3/OXA1/COX18
• Membrane insertase YidC/Oxa/ALB, C-terminal
• 60Kd inner membrane protein

KeywordsUniProt

• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Transit peptide
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of COX18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• COX20