Seroatlas · Human Serome Atlas

CORT

Cortistatin

Also known as: CORT_HUMAN, MGC32686, SST2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00230
Gene: CORT
Ensembl: ENSG00000241563
Chromosome: 1
Canonical length: 105 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>O00230|CORT
     1  MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL AWWFEWTSQA
    61  SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT FSSCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CORT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 67 nTPM
cerebral cortex: 20 nTPM
amygdala: 18 nTPM
hippocampal formation: 8.8 nTPM
hypothalamus: 4.4 nTPM
testis: 1.9 nTPM

Single-cell type

brain inhibitory neurons: 16 nCPM
late spermatids: 8.1 nCPM
hepatic stellate cells: 6.5 nCPM
late primary spermatocytes: 5.1 nCPM
early spermatids: 4.3 nCPM
other brain neurons: 3.3 nCPM

Immune cell

NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 26 nTPM
cerebral cortex: 10 nTPM
thalamus: 7.6 nTPM
white matter: 6.6 nTPM
amygdala: 6.4 nTPM
hypothalamus: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0.01
gnomAD missense Z: -1.55
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CORT as an antibody target. Whether an autoantibody or antibody against CORT could matter depends on whether native CORT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CORT is annotated as secreted, so native CORT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CORT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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