Seroatlas · Human Serome Atlas

CORO6

Coronin-6

Also known as: ClipinE, CORO6_HUMAN, FLJ14871

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6QEF8
Gene: CORO6
Ensembl: ENSG00000167549
Chromosome: 17
Canonical length: 472 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>Q6QEF8|CORO6
     1  MSRRVVRQSK FRHVFGQAAK ADQAYEDIRV SKVTWDSSFC AVNPKFLAII VEAGGGGAFI
    61  VLPLAKTGRV DKNYPLVTGH TAPVLDIDWC PHNDNVIASA SDDTTIMVWQ IPDYTPMRNI
   121  TEPIITLEGH SKRVGILSWH PTARNVLLSA GGDNVIIIWN VGTGEVLLSL DDMHPDVIHS
   181  VCWNSNGSLL ATTCKDKTLR IIDPRKGQVV AEQARPHEGA RPLRAVFTAD GKLLSTGFSR
   241  MSERQLALWD PNNFEEPVAL QEMDTSNGVL LPFYDPDSSI VYLCGKGDSS IRYFEITDEP
   301  PFVHYLNTFS SKEPQRGMGF MPKRGLDVSK CEIARFYKLH ERKCEPIIMT VPRKSDLFQD
   361  DLYPDTPGPE PALEADEWLS GQDAEPVLIS LRDGYVPPKH RELRVTKRNI LDVRPPSGPR
   421  RSQSASDAPL SQQHTLETLL EEIKALRERV QAQEQRITAL ENMLCELVDG TD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CORO6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 342 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 342 nTPM
tongue: 180 nTPM
thyroid gland: 42 nTPM
heart muscle: 41 nTPM
placenta: 17 nTPM
cerebral cortex: 16 nTPM

Single-cell type

thymic myoid cells: 135 nCPM
myonuclei: 118 nCPM
cardiomyocytes: 75 nCPM
extravillous trophoblasts: 62 nCPM
brain inhibitory neurons: 61 nCPM
other brain neurons: 49 nCPM

Immune cell

eosinophil: 0.5 nTPM
basophil: 0.3 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 45 nTPM
white matter: 32 nTPM
pons: 23 nTPM
basal ganglia: 18 nTPM
medulla oblongata: 15 nTPM
thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

actin filament organization
cell migration
negative regulation of cellular component organization

Molecular functions

actin filament binding

Cellular components

lamellipodium

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CORO6 as an antibody target. Whether an autoantibody or antibody against CORO6 could matter depends on whether native CORO6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CORO6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CORO6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...