Seroatlas · Human Serome Atlas

CORO2B

Coronin-2B

Also known as: ClipinC, COR2B_HUMAN, KIAA0925

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UQ03
Gene
CORO2B
Ensembl
ENSG00000103647
Chromosome
15
Canonical length
480 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Focal adhesion sites

OverviewNCBI Gene

Enables talin binding activity and vinculin binding activity. Acts upstream of or within several processes, including negative regulation of cell-substrate adhesion; regulation of actin cytoskeleton organization; and regulation of establishment of protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>Q9UQ03|CORO2B
     1  MTVTKMSWRP QYRSSKFRNV YGKVANREHC FDGIPITKNV HDNHFCAVNT RFLAIVTESA
    61  GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID NIIASCSEDT SVRIWEIPEG
   121  GLKRNMTEAL LELHGHSRRV GLVEWHPTTN NILFSAGYDY KVLIWNLDVG EPVKMIDCHT
   181  DVILCMSFNT DGSLLTTTCK DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT
   241  GVSRWNTRQI ALWDQEDLSM PLIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
   301  STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI EPISMIVPRR
   361  SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG YKKSSKMVFK APIKEKKSVV
   421  VNGIDLLENV PPRTENELLR MFFRQQDEIR RLKEELAQKD IRIRQLQLEL KNLRNSPKNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CORO2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 95 nTPM
  • cerebellum: 84 nTPM
  • basal ganglia: 69 nTPM
  • cerebral cortex: 64 nTPM
  • hippocampal formation: 55 nTPM
  • midbrain: 52 nTPM

Single-cell type

  • podocytes: 370 nCPM
  • ependymal cells: 293 nCPM
  • rod photoreceptor cells: 222 nCPM
  • retinal bipolar cells: 214 nCPM
  • cone photoreceptor cells: 191 nCPM
  • retinal ganglion cells: 174 nCPM

Immune cell

  • naive B-cell: 1.2 nTPM
  • memory B-cell: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • white matter: 149 nTPM
  • thalamus: 119 nTPM
  • cerebral cortex: 117 nTPM
  • medulla oblongata: 112 nTPM
  • midbrain: 112 nTPM
  • cerebellum: 111 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.06
gnomAD missense Z
2.19
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CORO2B as an antibody target. Whether an autoantibody or antibody against CORO2B could matter depends on whether native CORO2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CORO2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CORO2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CORO2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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