Seroatlas · Human Serome Atlas

CORO2A

Coronin-2A

Also known as: COR2A_HUMAN, IR10, WDR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92828
Gene: CORO2A
Ensembl: ENSG00000106789
Chromosome: 9
Canonical length: 525 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q92828|CORO2A
     1  MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV VTECAGGGAF
    61  LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFDDFEIAS CSEDATIKIW SIPKQLLTRN
   121  LTAYRKELVG HARRVGLVEW HPTAANILFS AGYDYKVMIW NLDTKESVIT SPMSTISCHQ
   181  DVILSMSFNT NGSLLATTCK DRKIRVIDPR AGTVLQEASY KGHRASKVLF LGNLKKLMST
   241  GTSRWNNRQV ALWDQDNLSV PLMEEDLDGS SGVLFPFYDA DTSMLYVVGK GDGNIRYYEV
   301  SADKPHLSYL TEYRSYNPQK GIGVMPKRGL DVSSCEIFRF YKLITTKSLI EPISMIVPRR
   361  SESYQEDIYP PTAGAQPSLT AQEWLSGMNR DPILVSLRPG SELLRPHPLP AERPIFNSMA
   421  PASPRLLNQT EKLAAEDGWR SSSLLEEKMP RWAAEHRLEE KKTWLTNGFD VFECPPPKTE
   481  NELLQMFYRQ QEEIRRLREL LTQREVQAKQ LELEIKNLRM GSEQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CORO2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

small intestine: 33 nTPM
duodenum: 32 nTPM
gallbladder: 17 nTPM
colon: 16 nTPM
esophagus: 14 nTPM
bone marrow: 14 nTPM

Single-cell type

enterocytes: 243 nCPM
prostatic hillock cells: 218 nCPM
sertoli cells: 207 nCPM
neutrophil progenitors: 182 nCPM
somatotrophs: 154 nCPM
papillary tip epithelial cells: 147 nCPM

Immune cell

T-reg: 12 nTPM
eosinophil: 11 nTPM
basophil: 11 nTPM
non-classical monocyte: 7.8 nTPM
MAIT T-cell: 5.2 nTPM
memory CD4 T-cell: 3.9 nTPM

Brain region

pons: 15 nTPM
cerebellum: 14 nTPM
thalamus: 14 nTPM
medulla oblongata: 12 nTPM
midbrain: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.75
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Molecular functions

actin filament binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CORO2A as an antibody target. Whether an autoantibody or antibody against CORO2A could matter depends on whether native CORO2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CORO2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CORO2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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