CORIN

Protein identityUniProt · HPA

UniProt accession

Q9Y5Q5

Gene

CORIN

Ensembl

ENSG00000145244

Chromosome

4

Canonical length

1042 aa

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Nuclear bodies,Plasma membrane,Actin filaments

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

1042 residues, UniProt reviewed canonical sequence.

>Q9Y5Q5|CORIN
     1  MKQSPALAPE ERCRRAGSPK PVLRADDNNM GNGCSQKLAT ANLLRFLLLV LIPCICALVL
    61  LLVILLSYVG TLQKVYFKSN GSEPLVTDGE IQGSDVILTN TIYNQSTVVS TAHPDQHVPA
   121  WTTDASLPGD QSHRNTSACM NITHSQCQML PYHATLTPLL SVVRNMEMEK FLKFFTYLHR
   181  LSCYQHIMLF GCTLAFPECI IDGDDSHGLL PCRSFCEAAK EGCESVLGMV NYSWPDFLRC
   241  SQFRNQTESS NVSRICFSPQ QENGKQLLCG RGENFLCASG ICIPGKLQCN GYNDCDDWSD
   301  EAHCNCSENL FHCHTGKCLN YSLVCDGYDD CGDLSDEQNC DCNPTTEHRC GDGRCIAMEW
   361  VCDGDHDCVD KSDEVNCSCH SQGLVECRNG QCIPSTFQCD GDEDCKDGSD EENCSVIQTS
   421  CQEGDQRCLY NPCLDSCGGS SLCDPNNSLN NCSQCEPITL ELCMNLPYNS TSYPNYFGHR
   481  TQKEASISWE SSLFPALVQT NCYKYLMFFS CTILVPKCDV NTGEHIPPCR ALCEHSKERC
   541  ESVLGIVGLQ WPEDTDCSQF PEENSDNQTC LMPDEYVEEC SPSHFKCRSG QCVLASRRCD
   601  GQADCDDDSD EENCGCKERD LWECPSNKQC LKHTVICDGF PDCPDYMDEK NCSFCQDDEL
   661  ECANHACVSR DLWCDGEADC SDSSDEWDCV TLSINVNSSS FLMVHRAATE HHVCADGWQE
   721  ILSQLACKQM GLGEPSVTKL IQEQEKEPRW LTLHSNWESL NGTTLHELLV NGQSCESRSK
   781  ISLLCTKQDC GRRPAARMNK RILGGRTSRP GRWPWQCSLQ SEPSGHICGC VLIAKKWVLT
   841  VAHCFEGREN AAVWKVVLGI NNLDHPSVFM QTRFVKTIIL HPRYSRAVVD YDISIVELSE
   901  DISETGYVRP VCLPNPEQWL EPDTYCYITG WGHMGNKMPF KLQEGEVRII SLEHCQSYFD
   961  MKTITTRMIC AGYESGTVDS CMGDSGGPLV CEKPGGRWTL FGLTSWGSVC FSKVLGPGVY
  1021  SNVSYFVEWI KRQIYIQTFL LN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CORIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

53 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CORIN.

Disease | AllUniProt

Conditions CORIN is implicated in, by any mechanism.

• Pre-eclampsia/eclampsia 5 (PEE5) MIM:614595
• Cardiomyopathy, familial hypertrophic, 30, atrial (CMH30) MIM:620734

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 222 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Preeclampsia/eclampsia 5
• Cardiomyopathy, familial hypertrophic, 30, atrial
• Atrial fibrillation
• Cardiomyopathy
• Myocardial fibrosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.23

gnomAD pLI

0

gnomAD missense Z

-0.17

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• female pregnancy
• peptide hormone processing
• regulation of blood pressure
• regulation of cardiac conduction
• regulation of renal sodium excretion
• regulation of systemic arterial blood pressure by atrial natriuretic peptide

Molecular functions

• endopeptidase activity
• serine-type endopeptidase activity

Cellular components

• actin cytoskeleton
• cell surface
• extracellular region
• nuclear body
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• SRCR domain
• Serine proteases, trypsin domain
• Low-density lipoprotein (LDL) receptor class A repeat
• Peptidase S1, PA clan
• Frizzled domain
• Low-density lipoprotein (LDL) receptor class A, conserved site
• Serine proteases, trypsin family, serine active site
• LDL receptor-like superfamily
• SRCR-like domain superfamily
• Frizzled cysteine-rich domain superfamily
• Low-density lipoprotein receptor domain class A
• Trypsin
• Fz domain
• Scavenger receptor cysteine-rich domain
• Atrial natriuretic peptide-converting enzyme corin
• Corin, cysteine-rich domain 1
• Corin, cysteine-rich domain 2

KeywordsUniProt

• Autocatalytic cleavage
• Cardiomyopathy
• Cell membrane
• Disulfide bond
• Glycoprotein
• Hydrolase
• Membrane
• Protease
• Repeat
• Secreted
• Serine protease
• Signal-anchor
• Transmembrane
• Transmembrane helix
• Zymogen