Seroatlas · Human Serome Atlas

COQ10B

Coenzyme Q-binding protein COQ10 homolog B, mitochondrial

Also known as: CQ10B_HUMAN, FLJ13448

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8M1
Gene: COQ10B
Ensembl: ENSG00000115520
Chromosome: 2
Canonical length: 238 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q9H8M1|COQ10B
     1  MAARTGHTAL RRVVSGCRPK SATAAGAQAP VRNGRYLASC GILMSRTLPL HTSILPKEIC
    61  ARTFFKITAP LINKRKEYSE RRILGYSMQE MYDVVSGVED YKHFVPWCKK SDVISKRSGY
   121  CKTRLEIGFP PVLERYTSVV TLVKPHLVKA SCTDGRLFNH LETIWRFSPG LPGYPRTCTL
   181  DFSISFEFRS LLHSQLATLF FDEVVKQMVA AFERRACKLY GPETNIPREL MLHEVHHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COQ10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 49 nTPM
adrenal gland: 40 nTPM
heart muscle: 36 nTPM
liver: 35 nTPM
urinary bladder: 31 nTPM
parathyroid gland: 29 nTPM

Single-cell type

syncytiotrophoblasts: 277 nCPM
neutrophils: 257 nCPM
esophageal apical cells: 156 nCPM
smooth muscle cells: 108 nCPM
basal keratinocytes: 99 nCPM
megakaryocytes: 99 nCPM

Immune cell

neutrophil: 101 nTPM
basophil: 78 nTPM
T-reg: 64 nTPM
eosinophil: 64 nTPM
MAIT T-cell: 56 nTPM
naive CD8 T-cell: 51 nTPM

Brain region

cerebral cortex: 38 nTPM
choroid plexus: 31 nTPM
white matter: 29 nTPM
hypothalamus: 29 nTPM
thalamus: 28 nTPM
pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.29
gnomAD missense Z: 1
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular respiration

Molecular functions

ubiquinone binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COQ10B as an antibody target. Whether an autoantibody or antibody against COQ10B could matter depends on whether native COQ10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COQ10B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COQ10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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