Seroatlas · Human Serome Atlas

COQ10A

Coenzyme Q-binding protein COQ10 homolog A, mitochondrial

Also known as: CQ10A_HUMAN, FLJ32452

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MF6
Gene: COQ10A
Ensembl: ENSG00000135469
Chromosome: 12
Canonical length: 247 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q96MF6|COQ10A
     1  MAWAGSRRVP AGTRAAAERC CRLSLSPGAQ PAPPPGPLPP PRPMRFLTSC SLLLPRAAQI
    61  LAAEAGLPSS RSFMGFAAPF TNKRKAYSER RIMGYSMQEM YEVVSNVQEY REFVPWCKKS
   121  LVVSSRKGHL KAQLEVGFPP VMERYTSAVS MVKPHMVKAV CTDGKLFNHL ETIWRFSPGI
   181  PAYPRTCTVD FSISFEFRSL LHSQLATMFF DEVVKQNVAA FERRAATKFG PETAIPRELM
   241  FHEVHQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COQ10A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 361 nTPM

Expression across tissuesHPA

Tissue

tongue: 361 nTPM
skeletal muscle: 263 nTPM
heart muscle: 158 nTPM
liver: 37 nTPM
choroid plexus: 37 nTPM
adrenal gland: 33 nTPM

Single-cell type

myonuclei: 238 nCPM
cardiomyocytes: 122 nCPM
thymic myoid cells: 113 nCPM
retinal pigment epithelial cells: 51 nCPM
adrenal cortex cells: 40 nCPM
fallopian tube ciliated cells: 33 nCPM

Immune cell

basophil: 14 nTPM
memory B-cell: 13 nTPM
naive CD4 T-cell: 8.3 nTPM
naive CD8 T-cell: 8.1 nTPM
memory CD8 T-cell: 7.8 nTPM
gdT-cell: 7.4 nTPM

Brain region

choroid plexus: 19 nTPM
thalamus: 14 nTPM
midbrain: 13 nTPM
hypothalamus: 12 nTPM
cerebellum: 11 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular respiration

Molecular functions

ubiquinone binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COQ10A as an antibody target. Whether an autoantibody or antibody against COQ10A could matter depends on whether native COQ10A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COQ10A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COQ10A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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