Seroatlas · Human Serome Atlas

COPZ2

Coatomer subunit zeta-2

Also known as: COPZ2_HUMAN, MGC23008

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P299
Gene: COPZ2
Ensembl: ENSG00000005243
Chromosome: 17
Canonical length: 210 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>Q9P299|COPZ2
     1  MQRPEAWPRP HPGEGAAAAQ AGGPAPPARA GEPSGLRLQE PSLYTIKAVF ILDNDGRRLL
    61  AKYYDDTFPS MKEQMVFEKN VFNKTSRTES EIAFFGGMTI VYKNSIDLFL YVVGSSYENE
   121  LMLMSVLTCL FESLNHMLRK NVEKRWLLEN MDGAFLVLDE IVDGGVILES DPQQVIQKVN
   181  FRADDGGLTE QSVAQVLQSA KEQIKWSLLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPZ2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 96 nTPM
skeletal muscle: 85 nTPM
adipose tissue: 67 nTPM
colon: 54 nTPM
heart muscle: 54 nTPM
choroid plexus: 46 nTPM

Single-cell type

hepatic stellate cells: 110 nCPM
decidual stromal cells: 77 nCPM
fibroblasts: 67 nCPM
breast myoepithelial cells: 60 nCPM
smooth muscle cells: 52 nCPM
endometrial stromal cells: 49 nCPM

Immune cell

classical monocyte: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
intermediate monocyte: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
non-classical monocyte: 0.2 nTPM

Brain region

choroid plexus: 33 nTPM
hypothalamus: 20 nTPM
medulla oblongata: 18 nTPM
white matter: 17 nTPM
spinal cord: 14 nTPM
thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: -0.12

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPZ2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

COPG1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPZ2 as an antibody target. Whether an autoantibody or antibody against COPZ2 could matter depends on whether native COPZ2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPZ2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPZ2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...