Seroatlas · Human Serome Atlas

COMTD1

Catechol O-methyltransferase domain-containing protein 1

Also known as: CMTD1_HUMAN, FLJ23841

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VU5
Gene: COMTD1
Ensembl: ENSG00000165644
Chromosome: 10
Canonical length: 262 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in methylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q86VU5|COMTD1
     1  MTQPVPRLSV PAALALGSAA LGAAFATGLF LGRRCPPWRG RREQCLLPPE DSRLWQYLLS
    61  RSMREHPALR SLRLLTLEQP QGDSMMTCEQ AQLLANLARL IQAKKALDLG TFTGYSALAL
   121  ALALPADGRV VTCEVDAQPP ELGRPLWRQA EAEHKIDLRL KPALETLDEL LAAGEAGTFD
   181  VAVVDADKEN CSAYYERCLQ LLRPGGILAV LRVLWRGKVL QPPKGDVAAE CVRNLNERIR
   241  RDVRVYISLL PLGDGLTLAF KI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

pancreas: 97 nTPM
esophagus: 51 nTPM
liver: 28 nTPM
heart muscle: 24 nTPM
skeletal muscle: 21 nTPM
kidney: 21 nTPM

Single-cell type

esophageal apical cells: 615 nCPM
esophageal suprabasal cells: 466 nCPM
enterocytes: 391 nCPM
esophageal basal cells: 379 nCPM
colonocytes: 252 nCPM
pancreatic acinar cells: 232 nCPM

Immune cell

plasmacytoid DC: 15 nTPM
MAIT T-cell: 12 nTPM
memory CD8 T-cell: 11 nTPM
gdT-cell: 11 nTPM
memory CD4 T-cell: 11 nTPM
intermediate monocyte: 10 nTPM

Brain region

choroid plexus: 13 nTPM
midbrain: 5 nTPM
hypothalamus: 4.4 nTPM
pons: 4.4 nTPM
medulla oblongata: 4.3 nTPM
thalamus: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

methylation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Class I-like SAM-dependent O-methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily
O-methyltransferase
Cation-dependent O-methyltransferase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMTD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KPNB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMTD1 as an antibody target. Whether an autoantibody or antibody against COMTD1 could matter depends on whether native COMTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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