Seroatlas · Human Serome Atlas

COLCA1

Colorectal cancer-associated protein 1

Also known as: COLC1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZS62
Gene: COLCA1
Canonical length: 124 aa

OverviewNCBI Gene

No narrative summary is available for COLCA1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>Q6ZS62|COLCA1
     1  MESCSVAQAG VLTSPFMWRW TGMAGALSAL DNTIEDDADD QLPCGEGRPG WVRGELLGSQ
    61  GVCKDSKDLF VPTSSSLYGC FCVGLVSGMA ISVLLLASDF RKLDFSRPEP CFEKEASLWF
   121  VAQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COLCA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.63

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.17

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COLCA1 as an antibody target. Whether an autoantibody or antibody against COLCA1 could matter depends on whether native COLCA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COLCA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COLCA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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