Seroatlas · Human Serome Atlas

CNTROB

Centrobin

Also known as: CNTRB_HUMAN, LIP8, PP1221

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N137
Gene
CNTROB
Ensembl
ENSG00000170037
Chromosome
17
Canonical length
903 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome,Basal body,Cytosol,Flagellar centriole

OverviewNCBI Gene

This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

903 residues, UniProt reviewed canonical sequence.

>Q8N137|CNTROB
     1  MATSADSPSS PLGAEDLLSD SSEPPGLNQV SSEVTSQLYA SLRLSRQAEA TARAQLYLPS
    61  TSPPHEGLDG FAQELSRSLS VGLEKNLKKK DGSKHIFEME SVRGQLQTML QTSRDTAYRD
   121  PLIPGAGSER REEDSFDSDS TATLLNTRPL QDLSPSSSAQ ALEELFPRYT SLRPGPPLNP
   181  PDFQGLRDAL DSEHTRRKHC ERHIQSLQTR VLELQQQLAV AVAADRKKDT MIEQLDKTLA
   241  RVVEGWNRHE AERTEVLRGL QEEHQAAELT RSKQQETVTR LEQSLSEAME ALNREQESAR
   301  LQQRERETLE EERQALTLRL EAEQQRCCVL QEERDAARAG QLSEHRELET LRAALEEERQ
   361  TWAQQEHQLK EHYQALQEES QAQLEREKEK SQREAQAAWE TQHQLALVQS EVRRLEGELD
   421  TARRERDALQ LEMSLVQARY ESQRIQLESE LAVQLEQRVT ERLAQAQESS LRQAASLREH
   481  HRKQLQDLSG QHQQELASQL AQFKVEMAER EERQQQVAED YELRLAREQA RVCELQSGNQ
   541  QLEEQRVELV ERLQAMLQAH WDEANQLLST TLPPPNPPAP PAGPSSPGPQ EPEKEERRVW
   601  TMPPMAVALK PVLQQSREAR DELPGAPPVL CSSSSDLSLL LGPSFQSQHS FQPLEPKPDL
   661  TSSTAGAFSA LGAFHPDHRA ERPFPEEDPG PDGEGLLKQG LPPAQLEGLK NFLHQLLETV
   721  PQNNENPSVD LLPPKSGPLT VPSWEEAPQV PRIPPPVHKT KVPLAMASSL FRVPEPPSSH
   781  SQGSGPSSGS PERGGDGLTF PRQLMEVSQL LRLYQARGWG ALPAEDLLLY LKRLEHSGTD
   841  GRGDNVPRRN TDSRLGEIPR KEIPSQAVPR RLATAPKTEK PPARKKSGHP APSSMRSRGG
   901  VWR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNTROB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • testis: 63 nTPM
  • endometrium: 38 nTPM
  • bone marrow: 30 nTPM
  • cervix: 29 nTPM
  • lung: 28 nTPM
  • thymus: 27 nTPM

Single-cell type

  • decidual stromal cells: 73 nCPM
  • early primary spermatocytes: 49 nCPM
  • late primary spermatocytes: 48 nCPM
  • alveolar cells type 2: 42 nCPM
  • monocyte progenitors: 39 nCPM
  • transitional alveolar cells: 38 nCPM

Immune cell

  • basophil: 6.5 nTPM
  • plasmacytoid DC: 5.3 nTPM
  • NK-cell: 2.6 nTPM
  • intermediate monocyte: 2.5 nTPM
  • memory CD8 T-cell: 2.4 nTPM
  • total PBMC: 2.1 nTPM

Brain region

  • thalamus: 18 nTPM
  • hypothalamus: 18 nTPM
  • white matter: 17 nTPM
  • cerebral cortex: 16 nTPM
  • medulla oblongata: 16 nTPM
  • midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
0.67
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Centrobin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNTROB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNTROB as an antibody target. Whether an autoantibody or antibody against CNTROB could matter depends on whether native CNTROB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNTROB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNTROB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNTROB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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