Seroatlas · Human Serome Atlas

CNTN6

Contactin-6

Also known as: CNTN6_HUMAN, NB-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UQ52
Gene: CNTN6
Ensembl: ENSG00000134115
Chromosome: 3
Canonical length: 1028 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

1028 residues, UniProt reviewed canonical sequence.

>Q9UQ52|CNTN6
     1  MRLLWKLVIL LPLINSSAGD GLLSRPIFTQ EPHDVIFPLD LSKSEVILNC AANGYPSPHY
    61  RWKQNGTDID FTMSYHYRLD GGSLAINSPH TDQDIGMYQC LATNLLGTIL SRKAKLQFAY
   121  IEDFETKTRS TVSVREGQGV VLLCGPPPHF GDLSYAWTFN DNPLYVQEDN RRFVSQETGN
   181  LYIAKVEPSD VGNYTCFITN KEAQRSVQGP PTPLVQRTDG VMGEYEPKIE VRFPETIQAA
   241  KDSSVKLECF ALGNPVPDIS WRRLDGSPLP GKVKYSKSQA ILEIPNFQQE DEGFYECIAS
   301  NLRGRNLAKG QLIFYAPPEW EQKIQNTHLS IYDNLLWECK ASGKPNPWYT WLKNGERLNP
   361  EERIQIENGT LIITMLNVSD SGVYQCAAEN KYQIIYANAE LRVLASAPDF SKSPVKKKSF
   421  VQVGGDIVIG CKPNAFPRAA ISWKRGTETL RQSKRIFLLE DGSLKIYNIT RSDAGSYTCI
   481  ATNQFGTAKN TGSLIVKERT VITVPPSKMD VTVGESIVLP CQVSHDPSIE VVFVWFFNGD
   541  VIDLKKGVAH FERIGGESVG DLMIRNIQLH HSGKYLCTVQ TTLESLSAVA DIIVRGPPGP
   601  PEDVQVEDIS STTSQLSWRA GPDNNSPIQI FTIQTRTPFS VGWQAVATVP EILNGKTYNA
   661  TVVGLSPWVE YEFRVVAGNS IGIGEPSEPS ELLRTKASVP VVAPVNIHGG GGSRSELVIT
   721  WESIPEELQN GEGFGYIIMF RPVGSTTWSK EKVSSVESSR FVYRNESIIP LSPFEVKVGV
   781  YNNEGEGSLS TVTIVYSGED EPQLAPRGTS LQSFSASEME VSWNAIAWNR NTGRVLGYEV
   841  LYWTDDSKES MIGKIRVSGN VTTKNITGLK ANTIYFASVR AYNTAGTGPS SPPVNVTTKK
   901  SPPSQPPANI AWKLTNSKLC LNWEHVKTME NESEVLGYKI LYRQNRQSKT HILETNNTSA
   961  ELLVPFEEDY LIEIRTVSDG GDGSSSEEIR IPKMSSLSSR GIQFLEPSTH FLSIVIVIFH
  1021  CFAIQPLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNTN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 9 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 9 nTPM
cerebellum: 8.8 nTPM
adrenal gland: 3.2 nTPM
lung: 3 nTPM
cerebral cortex: 2.4 nTPM
placenta: 1.9 nTPM

Single-cell type

adrenal cortex cells: 445 nCPM
alveolar cells type 1: 224 nCPM
brain excitatory neurons: 186 nCPM
pituicytes/fscs: 145 nCPM
oligodendrocyte progenitor cells: 80 nCPM
transitional alveolar cells: 80 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 25 nTPM
hypothalamus: 8.4 nTPM
pons: 6.9 nTPM
cerebral cortex: 6.4 nTPM
medulla oblongata: 5.7 nTPM
thalamus: 5.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CNTN6.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 244 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -3
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cell-cell adhesion mediator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNTN6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PTPRG

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNTN6 as an antibody target. Whether an autoantibody or antibody against CNTN6 could matter depends on whether native CNTN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNTN6 is annotated at the cell surface, where native CNTN6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CNTN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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