Seroatlas · Human Serome Atlas

CNPY4

Protein canopy homolog 4

Also known as: CNPY4_HUMAN, MGC40499, PRAT4B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N129
Gene: CNPY4
Ensembl: ENSG00000166997
Chromosome: 7
Canonical length: 248 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Involved in positive regulation of protein localization to plasma membrane. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q8N129|CNPY4
     1  MGPVRLGILL FLFLAVHEAW AGMLKEEDDD TERLPSKCEV CKLLSTELQA ELSRTGRSRE
    61  VLELGQVLDT GKRKRHVPYS VSETRLEEAL ENLCERILDY SVHAERKGSL RYAKGQSQTM
   121  ATLKGLVQKG VKVDLGIPLE LWDEPSVEVT YLKKQCETML EEFEDIVGDW YFHHQEQPLQ
   181  NFLCEGHVLP AAETACLQET WTGKEITDGE EKTEGEEEQE EEEEEEEEEG GDKMTKTGSH
   241  PKLDREDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNPY4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

ovary: 31 nTPM
cervix: 24 nTPM
choroid plexus: 22 nTPM
placenta: 20 nTPM
smooth muscle: 20 nTPM
blood vessel: 20 nTPM

Single-cell type

decidual stromal cells: 57 nCPM
hepatic stellate cells: 52 nCPM
cytotrophoblasts: 46 nCPM
peritubular myoid cells: 30 nCPM
leydig cells: 28 nCPM
ovarian stromal cells: 26 nCPM

Immune cell

MAIT T-cell: 20 nTPM
naive CD8 T-cell: 19 nTPM
memory CD8 T-cell: 19 nTPM
memory CD4 T-cell: 16 nTPM
gdT-cell: 15 nTPM
non-classical monocyte: 14 nTPM

Brain region

choroid plexus: 11 nTPM
medulla oblongata: 10 nTPM
cerebellum: 9.8 nTPM
white matter: 9.6 nTPM
basal ganglia: 9.1 nTPM
midbrain: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -0.25
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNPY4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TLR4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNPY4 as an antibody target. Whether an autoantibody or antibody against CNPY4 could matter depends on whether native CNPY4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNPY4 is annotated as secreted, so native CNPY4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CNPY4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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