Seroatlas · Human Serome Atlas

CNPY1

Protein canopy homolog 1

Also known as: CNPY1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3B7I2
Gene
CNPY1
Ensembl
ENSG00000146910
Chromosome
7
Canonical length
92 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Cnpy1 is expressed in the midbrain-hindbrain (MHB) boundary in zebrafish, binds FGFR1 (MIM 136350), and plays a role in FGF signaling (Hirate and Okamoto, 2006 [PubMed 16488878]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>Q3B7I2|CNPY1
     1  MNDYKLEEDP VTKERTFKRF APRKGDKIYQ EFKKLYFYSD AYRPLKFACE TIIEEYEDEI
    61  SSLIAQETHY LADKLCSEKS DLCETSANHT EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNPY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
8.5 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 8.5 nTPM
  • pancreas: 2.2 nTPM
  • retina: 0.5 nTPM
  • epididymis: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • testis: 0.2 nTPM

Single-cell type

  • podocytes: 1.3 nCPM
  • epididymal efferent duct absorptive cells: 0.8 nCPM
  • bergmann glia: 0.4 nCPM
  • early primary spermatocytes: 0.4 nCPM
  • papillary tip epithelial cells: 0.4 nCPM
  • proximal tubule cells: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 26 nTPM
  • midbrain: 8.6 nTPM
  • pons: 3.6 nTPM
  • white matter: 2.4 nTPM
  • cerebral cortex: 2 nTPM
  • amygdala: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
-0.04
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNPY1 as an antibody target. Whether an autoantibody or antibody against CNPY1 could matter depends on whether native CNPY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNPY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNPY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNPY1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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