Seroatlas · Human Serome Atlas

CNPPD1

Protein CNPPD1

Also known as: C2orf24, CGI-57, CNPD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BV87
Gene: CNPPD1
Ensembl: ENSG00000115649
Chromosome: 2
Canonical length: 410 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be located in membrane. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q9BV87|CNPPD1
     1  MDLTGLLLDE EGTFSLAGFQ DFTFLPGHQK LSARIRRRLY YGWDWEADCS LEELSSPVAD
    61  IAVELLQKAA PSPIRRLQKK YVAHVSREAC ISPCAMMLAL VYIERLRHRN PDYLQHVSSS
   121  DLFLISMMVA SKYLYDEGEE EEVFNDEWGA AGGVAVPTLN ALERGFLSAM DWHLYTDPRE
   181  IFEVLSWLES CVAEQQGRWR GWYTYTDLCV LLEQPTWQLA LGSLCQRLVK LSCLLAVAYV
   241  SSVALAVASV AVIHQSLGLS CIPTPGPPDL GLTSRCLLEP CIPSVPQCLP SLANVSSCLE
   301  GSMGLRSLWG SLLASLTPPP LPPPDPPAPP TLLHNCHLCQ KLQRDSPTCH ACLHPNRTVP
   361  TALSSPWYHT YGLAPPWPWS PVLLSLPQPQ QCSLFSVMEL ARLKSFVFPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNPPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 93 nTPM
adrenal gland: 87 nTPM
kidney: 86 nTPM
parathyroid gland: 84 nTPM
esophagus: 79 nTPM
bone marrow: 74 nTPM

Single-cell type

esophageal apical cells: 206 nCPM
colonocytes: 80 nCPM
adrenal cortex cells: 75 nCPM
esophageal suprabasal cells: 74 nCPM
syncytiotrophoblasts: 74 nCPM
enterocytes: 74 nCPM

Immune cell

non-classical monocyte: 123 nTPM
myeloid DC: 98 nTPM
intermediate monocyte: 95 nTPM
naive B-cell: 88 nTPM
basophil: 83 nTPM
memory B-cell: 80 nTPM

Brain region

white matter: 67 nTPM
medulla oblongata: 60 nTPM
cerebellum: 57 nTPM
basal ganglia: 54 nTPM
spinal cord: 54 nTPM
midbrain: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNPPD1 as an antibody target. Whether an autoantibody or antibody against CNPPD1 could matter depends on whether native CNPPD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNPPD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNPPD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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