Seroatlas · Human Serome Atlas

CNMD

Leukocyte cell-derived chemotaxin 1

Also known as: BRICD3, CHM-I, CHM1, CNMD_HUMAN, LECT1, MYETS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75829
Gene: CNMD
Ensembl: ENSG00000136110
Chromosome: 13
Canonical length: 334 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>O75829|CNMD
     1  MTENSDKVPI ALVGPDDVEF CSPPAYATLT VKPSSPARLL KVGAVVLISG AVLLLFGAIG
    61  AFYFWKGSDS HIYNVHYTMS INGKLQDGSM EIDAGNNLET FKMGSGAEEA IAVNDFQNGI
   121  TGIRFAGGEK CYIKAQVKAR IPEVGAVTKQ SISSKLEGKI MPVKYEENSL IWVAVDQPVK
   181  DNSFLSSKVL ELCGDLPIFW LKPTYPKEIQ RERREVVRKI VPTTTKRPHS GPRSNPGAGR
   241  LNNETRPSVQ EDSQAFNPDN PYHQQEGESM TFDPRLDHEG ICCIECRRSY THCQKICEPL
   301  GGYYPWPYNY QGCRSACRVI MPCSWWVARI LGMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNMD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 12 nTPM
retina: 7.7 nTPM
basal ganglia: 6.4 nTPM
salivary gland: 6.3 nTPM
spinal cord: 3.4 nTPM
thyroid gland: 3.1 nTPM

Single-cell type

müller glia: 109 nCPM
retinal amacrine cells: 23 nCPM
early primary spermatocytes: 16 nCPM
epicardial cells: 16 nCPM
oligodendrocyte progenitor cells: 16 nCPM
retinal pigment epithelial cells: 8.5 nCPM

Immune cell

T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 10 nTPM
choroid plexus: 7 nTPM
spinal cord: 5.9 nTPM
white matter: 5.7 nTPM
medulla oblongata: 5.3 nTPM
thalamus: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

endomembrane system

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNMD as an antibody target. Whether an autoantibody or antibody against CNMD could matter depends on whether native CNMD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNMD is annotated as secreted, so native CNMD circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CNMD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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