Seroatlas · Human Serome Atlas

CNIH3

Protein cornichon homolog 3

Also known as: CNIH-3, CNIH3_HUMAN, FLJ38993

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBE1
Gene: CNIH3
Ensembl: ENSG00000143786
Chromosome: 1
Canonical length: 160 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable channel regulator activity and signaling receptor binding activity. Involved in regulation of AMPA receptor activity. Predicted to be located in dendritic shaft and postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendrite and glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q8TBE1|CNIH3
     1  MAFTFAAFCY MLSLVLCAAL IFFAIWHIIA FDELRTDFKS PIDQCNPVHA RERLRNIERI
    61  CFLLRKLVLP EYSIHSLFCI MFLCAQEWLT LGLNVPLLFY HFWRYFHCPA DSSELAYDPP
   121  VVMNADTLSY CQKEAWCKLA FYLLSFFYYL YCMIYTLVSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNIH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 11 nTPM
hippocampal formation: 10 nTPM
pancreas: 7.4 nTPM
amygdala: 6.9 nTPM
hypothalamus: 5.3 nTPM
basal ganglia: 5.2 nTPM

Single-cell type

pituicytes/fscs: 118 nCPM
late spermatids: 117 nCPM
podocytes: 112 nCPM
bergmann glia: 111 nCPM
astrocytes: 109 nCPM
ependymal cells: 108 nCPM

Immune cell

NK-cell: 0.3 nTPM
memory B-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

hypothalamus: 25 nTPM
hippocampal formation: 23 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 12 nTPM
medulla oblongata: 12 nTPM
midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.85
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNIH3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GRIA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNIH3 as an antibody target. Whether an autoantibody or antibody against CNIH3 could matter depends on whether native CNIH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNIH3 is annotated at the cell surface, where native CNIH3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CNIH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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