Seroatlas · Human Serome Atlas

CNGA4

Cyclic nucleotide-gated channel alpha-4

Also known as: CNCA2, CNG5, CNGA4_HUMAN, CNGB2, OCNC2, OCNCb

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IV77
Gene: CNGA4
Ensembl: ENSG00000132259
Chromosome: 11
Canonical length: 575 aa
Protein class: Predicted membrane proteins, Voltage-gated ion channels
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q8IV77|CNGA4
     1  MSQDTKVKTT ESSPPAPSKA RKLLPVLDPS GDYYYWWLNT MVFPVMYNLI ILVCRACFPD
    61  LQHGYLVAWL VLDYTSDLLY LLDMVVRFHT GFLEQGILVV DKGRISSRYV RTWSFFLDLA
   121  SLMPTDVVYV RLGPHTPTLR LNRFLRAPRL FEAFDRTETR TAYPNAFRIA KLMLYIFVVI
   181  HWNSCLYFAL SRYLGFGRDA WVYPDPAQPG FERLRRQYLY SFYFSTLILT TVGDTPPPAR
   241  EEEYLFMVGD FLLAVMGFAT IMGSMSSVIY NMNTADAAFY PDHALVKKYM KLQHVNRKLE
   301  RRVIDWYQHL QINKKMTNEV AILQHLPERL RAEVAVSVHL STLSRVQIFQ NCEASLLEEL
   361  VLKLQPQTYS PGEYVCRKGD IGQEMYIIRE GQLAVVADDG ITQYAVLGAG LYFGEISIIN
   421  IKGNMSGNRR TANIKSLGYS DLFCLSKEDL REVLSEYPQA QTIMEEKGRE ILLKMNKLDV
   481  NAEAAEIALQ EATESRLRGL DQQLDDLQTK FARLLAELES SALKIAYRIE RLEWQTREWP
   541  MPEDLAEADD EGEPEEGTSK DEEGRASQEG PPGPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNGA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 16 nTPM
testis: 5.9 nTPM
basal ganglia: 1.3 nTPM
lung: 1.3 nTPM
hippocampal formation: 1.2 nTPM
amygdala: 1 nTPM

Single-cell type

late primary spermatocytes: 22 nCPM
breast myoepithelial cells: 22 nCPM
epididymal basal cells: 20 nCPM
early spermatids: 20 nCPM
ependymal cells: 19 nCPM
erythrocyte progenitors: 19 nCPM

Immune cell

eosinophil: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 7.6 nTPM
medulla oblongata: 5.5 nTPM
pons: 3.7 nTPM
white matter: 3.3 nTPM
spinal cord: 3.2 nTPM
hippocampal formation: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNGA4 as an antibody target. Whether an autoantibody or antibody against CNGA4 could matter depends on whether native CNGA4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNGA4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNGA4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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