CNGA2

Protein identityUniProt · HPA

UniProt accession

Q16280

Gene

CNGA2

Ensembl

ENSG00000183862

Chromosome

X

Canonical length

664 aa

Protein class

Predicted membrane proteins, Voltage-gated ion channels

OverviewNCBI Gene

The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

664 residues, UniProt reviewed canonical sequence.

>Q16280|CNGA2
     1  MTEKTNGVKS SPANNHNHHA PPAIKANGKD DHRTSSRPHS AADDDTSSEL QRLADVDAPQ
    61  QGRSGFRRIV RLVGIIREWA NKNFREEEPR PDSFLERFRG PELQTVTTQE GDGKGDKDGE
   121  DKGTKKKFEL FVLDPAGDWY YCWLFVIAMP VLYNWCLLVA RACFSDLQKG YYLVWLVLDY
   181  VSDVVYIADL FIRLRTGFLE QGLLVKDTKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVDI
   241  HSPEVRFNRL LHFARMFEFF DRTETRTNYP NIFRISNLVL YILVIIHWNA CIYYAISKSI
   301  GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY LFVIFDFLIG
   361  VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK VSKGMEAKVI RWFDYLWTNK
   421  KTVDEREILK NLPAKLRAEI AINVHLSTLK KVRIFHDCEA GLLVELVLKL RPQVFSPGDY
   481  ICRKGDIGKE MYIIKEGKLA VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI
   541  RSLGYSDLFC LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA TSMEVDVQEK
   601  LGQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLETKM KQNNEDDYLS DGMNSPELAA
   661  ADEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNGA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

0.2 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.79

gnomAD pLI

0

gnomAD missense Z

-0.03

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium ion transport
• monoatomic cation transmembrane transport
• potassium ion transport
• sensory perception of chemical stimulus
• sensory perception of smell
• sodium ion transport

Molecular functions

• calcium channel activity
• calmodulin binding
• cAMP binding
• cGMP binding
• intracellularly cAMP-activated cation channel activity
• intracellularly cGMP-activated cation channel activity

Cellular components

• ciliary membrane
• Golgi-associated vesicle membrane
• intracellular cyclic nucleotide activated cation channel complex
• non-motile cilium membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Cyclic nucleotide-binding domain
• Ion transport domain
• RmlC-like jelly roll fold
• Cyclic nucleotide-binding, conserved site
• Cyclic nucleotide-binding domain superfamily
• Cyclic nucleotide-gated channel, C-terminal leucine zipper domain
• Cyclic nucleotide-gated cation channel
• Cyclic nucleotide-binding domain
• Ion transport protein
• C-terminal leucine zipper domain of cyclic nucleotide-gated channels

KeywordsUniProt

• Calcium
• Calcium channel
• Calcium transport
• Calmodulin-binding
• cAMP
• cAMP-binding
• Cell membrane
• Cell projection
• cGMP
• cGMP-binding
• Coiled coil
• Ion channel
• Ion transport
• Ligand-gated ion channel
• Membrane
• Nucleotide-binding
• Olfaction
• Sensory transduction
• Transmembrane
• Transmembrane helix
• Transport