Seroatlas · Human Serome Atlas

CNFN

Cornifelin

Also known as: CNFN_HUMAN, PLAC8L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BYD5
Gene
CNFN
Ensembl
ENSG00000105427
Chromosome
19
Canonical length
112 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge

OverviewNCBI Gene

Predicted to be involved in keratinization. Located in cornified envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>Q9BYD5|CNFN
     1  MSYPVTSQPQ CATTSCYQTQ LSDWHTGLTD CCNDMPVCLC GTFAPLCLAC RISDDFGECC
    61  CAPYLPGGLH SIRTGMRERY HIQGSVGHDW AALTFCLPCA LCQMARELKI RE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNFN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
2,986 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 2,986 nTPM
  • vagina: 1,350 nTPM
  • cervix: 1,124 nTPM
  • salivary gland: 569 nTPM
  • skin: 529 nTPM
  • tonsil: 259 nTPM

Single-cell type

  • esophageal apical cells: 99,030 nCPM
  • suprabasal keratinocytes: 1,236 nCPM
  • esophageal suprabasal cells: 477 nCPM
  • esophageal basal cells: 135 nCPM
  • epididymal principal cells: 130 nCPM
  • submucosal glandular cells: 107 nCPM

Immune cell

  • naive B-cell: 71 nTPM
  • memory B-cell: 61 nTPM
  • myeloid DC: 5.9 nTPM
  • classical monocyte: 4.7 nTPM
  • intermediate monocyte: 3.9 nTPM
  • total PBMC: 2.2 nTPM

Brain region

  • basal ganglia: 6.8 nTPM
  • hypothalamus: 4.1 nTPM
  • cerebral cortex: 2.5 nTPM
  • midbrain: 2.1 nTPM
  • cerebellum: 2 nTPM
  • hippocampal formation: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.36
gnomAD pLI
0.03
gnomAD missense Z
0.27
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNFN as an antibody target. Whether an autoantibody or antibody against CNFN could matter depends on whether native CNFN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNFN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNFN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNFN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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