Seroatlas · Human Serome Atlas

CNBD2

Cyclic nucleotide-binding domain-containing protein 2

Also known as: C20orf152, CNBD2_HUMAN, CNMPD1, dJ954P9.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M20
Gene: CNBD2
Ensembl: ENSG00000149646
Chromosome: 20
Canonical length: 576 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Actin filaments,Cytosol,Mid piece

OverviewNCBI Gene

Predicted to enable cAMP binding activity. Predicted to be involved in spermatogenesis. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

576 residues, UniProt reviewed canonical sequence.

>Q96M20|CNBD2
     1  MRRHMVTYAW QLLKKELGLY QLAMDIIIMI RVCKMFRQGL RGFREYQIIE TAHWKHPIFS
    61  FWDKKMQSRV TFDTMDFIAE EGHFPPKAIQ IMQKKPSWRT EDEIQAVCNI LQVLDSYRNY
   121  AEPLQLLLAK VMRFERFGRR RVIIKKGQKG NSFYFIYLGT VAITKDEDGS SAFLDPHPKL
   181  LHKGSCFGEM DVLHASVRRS TIVCMEETEF LVVDREDFFA NKLDQEVQKD AQYRFEFFRK
   241  MELFASWSDE KLWQLVAMAK IERFSYGQLI SKDFGESPFI MFISKGSCEV LRLLDLGASP
   301  SYRRWIWQHL ELIDGRPLKT HLSEYSPMER FKEFQIKSYP LQDFSSLKLP HLKKAWGLQG
   361  TSFSRKIRTS GDTLPKMLGP KIQSRPAQSI KCAMINIKPG ELPKEAAVGA YVKVHTVEQG
   421  EILGLHQAFL PEGECDTRPL ILMSLGNELI RIRKEIFYEL IDNDDEMIKK LLKLNIAFPS
   481  DEDMCQKFLQ QNSWNIFRKD LLQLLVEPCQ SQLFTPNRPK KREIYNPKSV VLDLCSINKT
   541  TKPRYPIFMA PQKYLPPLRI VQAIKAPRYK IRELLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNBD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
skeletal muscle: 22 nTPM
tongue: 16 nTPM
retina: 15 nTPM
epididymis: 12 nTPM
cerebellum: 8.5 nTPM

Single-cell type

early spermatids: 353 nCPM
late primary spermatocytes: 153 nCPM
late spermatids: 147 nCPM
epididymal principal cells: 65 nCPM
rod photoreceptor cells: 33 nCPM
thymic myoid cells: 30 nCPM

Immune cell

NK-cell: 3.7 nTPM
T-reg: 3.4 nTPM
naive B-cell: 2.2 nTPM
basophil: 2 nTPM
intermediate monocyte: 2 nTPM
gdT-cell: 1.5 nTPM

Brain region

choroid plexus: 3.2 nTPM
cerebellum: 3 nTPM
white matter: 2.9 nTPM
medulla oblongata: 2.7 nTPM
midbrain: 2.5 nTPM
hypothalamus: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNBD2 as an antibody target. Whether an autoantibody or antibody against CNBD2 could matter depends on whether native CNBD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNBD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNBD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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