Seroatlas · Human Serome Atlas

CNBD1

Cyclic nucleotide-binding domain-containing protein 1

Also known as: CNBD1_HUMAN, FLJ35802

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA66
Gene: CNBD1
Ensembl: ENSG00000176571
Chromosome: 8
Canonical length: 436 aa
Protein class: Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CNBD1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q8NA66|CNBD1
     1  MPMSSLPAAI LSHMTAINNV PPPPLHSIPN LKKSKHINYG QLNALCHIRG QHSRSMSNIL
    61  SAHDTFMKQY PKVFLHQKPR LPKLFKQEEQ RELNEGKEES QHQQPDDSNN IAVHVQRAHG
   121  GHILYRPKRA TEKFEEFLAI LKKLPIHRTP YEHKTVWKFL KTIPDLTFQL NDKHLKTLSK
   181  TVFSETWLKG STVVANDGFY VILKGLARPQ TNVYKNLIEG SDSPDSFISQ SFHSFIWSEE
   241  FKNSTLAEMY LPSYDSMLSK WSTFGTLEVM PQNESETQMF SVVTEDDCEI LKIPAKGYAK
   301  IKEEKIKLEN MQKLKLIRMC PYYEEWPTLS IYELIALLKW KKFPPGHVIV ESGNIISFVG
   361  YINSGCCNIY RSIIGFVKLR SNKVKRSQKL VYMGKLKEKE SFGEISVLLQ VPFTCTIITK
   421  KEVEMAIIED KDLFVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNBD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

testis: 4.7 nTPM
spleen: 0.3 nTPM
retina: 0.1 nTPM
stomach: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late primary spermatocytes: 384 nCPM
retinal pigment epithelial cells: 375 nCPM
early spermatids: 249 nCPM
late spermatids: 156 nCPM
cone photoreceptor cells: 58 nCPM
undifferentiated spermatogonia: 47 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.6 nTPM
white matter: 0.6 nTPM
basal ganglia: 0.4 nTPM
hypothalamus: 0.4 nTPM
medulla oblongata: 0.4 nTPM
hippocampal formation: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -1.33
DepMap mean gene effect: 0.28
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNBD1 as an antibody target. Whether an autoantibody or antibody against CNBD1 could matter depends on whether native CNBD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNBD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNBD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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