Seroatlas · Human Serome Atlas

CMTR1

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

Also known as: CMTR1_HUMAN, FTSJD2, ISG95, KIAA0082, MTr1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1G2
Gene: CMTR1
Ensembl: ENSG00000137200
Chromosome: 6
Canonical length: 835 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

835 residues, UniProt reviewed canonical sequence.

>Q8N1G2|CMTR1
     1  MKRRTDPECT APIKKQKKRV AELALSLSST SDDEPPSSVS HGAKASTTSL SGSDSETEGK
    61  QHSSDSFDDA FKADSLVEGT SSRYSMYNSV SQKLMAKMGF REGEGLGKYS QGRKDIVEAS
   121  SQKGRRGLGL TLRGFDQELN VDWRDEPEPS ACEQVSWFPE CTTEIPDTQE MSDWMVVGKR
   181  KMIIEDETEF CGEELLHSVL QCKSVFDVLD GEEMRRARTR ANPYEMIRGV FFLNRAAMKM
   241  ANMDFVFDRM FTNPRDSYGK PLVKDREAEL LYFADVCAGP GGFSEYVLWR KKWHAKGFGM
   301  TLKGPNDFKL EDFYSASSEL FEPYYGEGGI DGDGDITRPE NISAFRNFVL DNTDRKGVHF
   361  LMADGGFSVE GQENLQEILS KQLLLCQFLM ALSIVRTGGH FICKTFDLFT PFSVGLVYLL
   421  YCCFERVCLF KPITSRPANS ERYVVCKGLK VGIDDVRDYL FAVNIKLNQL RNTDSDVNLV
   481  VPLEVIKGDH EFTDYMIRSN ESHCSLQIKA LAKIHAFVQD TTLSEPRQAE IRKECLRLWG
   541  IPDQARVAPS SSDPKSKFFE LIQGTEIDIF SYKPTLLTSK TLEKIRPVFD YRCMVSGSEQ
   601  KFLIGLGKSQ IYTWDGRQSD RWIKLDLKTE LPRDTLLSVE IVHELKGEGK AQRKISAIHI
   661  LDVLVLNGTD VREQHFNQRI QLAEKFVKAV SKPSRPDMNP IRVKEVYRLE EMEKIFVRLE
   721  MKIIKGSSGT PKLSYTGRDD RHFVPMGLYI VRTVNEPWTM GFSKSFKKKF FYNKKTKDST
   781  FDLPADSIAP FHICYYGRLF WEWGDGIRVH DSQKPQDQDK LSKEDVLSFI QMHRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

testis: 61 nTPM
cerebellum: 30 nTPM
bone marrow: 29 nTPM
thymus: 29 nTPM
skeletal muscle: 29 nTPM
spleen: 28 nTPM

Single-cell type

sertoli cells: 131 nCPM
cone photoreceptor cells: 46 nCPM
cytotrophoblasts: 37 nCPM
early spermatids: 35 nCPM
syncytiotrophoblasts: 32 nCPM
adrenal medulla cells: 32 nCPM

Immune cell

intermediate monocyte: 7.1 nTPM
T-reg: 6.1 nTPM
NK-cell: 5.6 nTPM
non-classical monocyte: 5.6 nTPM
memory B-cell: 5.5 nTPM
classical monocyte: 5.4 nTPM

Brain region

hypothalamus: 41 nTPM
cerebral cortex: 39 nTPM
thalamus: 38 nTPM
medulla oblongata: 37 nTPM
midbrain: 36 nTPM
basal ganglia: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 3.32
DepMap mean gene effect: -0.81
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G-patch domain
WW domain
Ribosomal RNA methyltransferase, FtsJ domain
S-adenosyl-L-methionine-dependent methyltransferase superfamily
mRNA Cap 2'-O-Ribose Methyltransferase
G-patch domain
FtsJ-like methyltransferase
RrmJ-type ribose 2-O-methyltransferase domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CMTR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

POLR2A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTR1 as an antibody target. Whether an autoantibody or antibody against CMTR1 could matter depends on whether native CMTR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMTR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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