Seroatlas · Human Serome Atlas

CMTM8

CKLF-like MARVEL transmembrane domain-containing protein 8

Also known as: CKLF8_HUMAN, CKLFSF8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZV2
Gene: CMTM8
Ensembl: ENSG00000170293
Chromosome: 3
Canonical length: 173 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>Q8IZV2|CMTM8
     1  MEEPQRARSH TVTTTASSFA ENFSTSSSSF AYDREFLRTL PGFLIVAEIV LGLLVWTLIA
    61  GTEYFRVPAF GWVMFVAVFY WVLTVFFLII YITMTYTRIP QVPWTTVGLC FNGSAFVLYL
   121  SAAVVDASSV SPERDSHNFN SWAASSFFAF LVTICYAGNT YFSFIAWRSR TIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTM8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

pancreas: 45 nTPM
liver: 39 nTPM
salivary gland: 19 nTPM
lung: 17 nTPM
epididymis: 16 nTPM
placenta: 16 nTPM

Single-cell type

breast lactating cells: 384 nCPM
salivary ionocytes: 352 nCPM
medullary thymic epithelial cells: 300 nCPM
pancreatic acinar cells: 262 nCPM
respiratory ionocytes: 236 nCPM
cytotrophoblasts: 231 nCPM

Immune cell

eosinophil: 1.6 nTPM
memory CD4 T-cell: 0.9 nTPM
naive CD4 T-cell: 0.6 nTPM
memory CD8 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

thalamus: 9.4 nTPM
pons: 8 nTPM
choroid plexus: 7.4 nTPM
amygdala: 7.3 nTPM
medulla oblongata: 7.3 nTPM
basal ganglia: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.06
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTM8 as an antibody target. Whether an autoantibody or antibody against CMTM8 could matter depends on whether native CMTM8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTM8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMTM8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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