Seroatlas · Human Serome Atlas

CMTM7

CKLF-like MARVEL transmembrane domain-containing protein 7

Also known as: CKLF7_HUMAN, CKLFSF7, FLJ30992

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FZ5
Gene: CMTM7
Ensembl: ENSG00000153551
Chromosome: 3
Canonical length: 175 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>Q96FZ5|CMTM7
     1  MSHGAGLVRT TCSSGSALGP GAGAAQPSAS PLEGLLDLSY PRTHAALLKV AQMVTLLIAF
    61  ICVRSSLWTN YSAYSYFEVV TICDLIMILA FYLVHLFRFY RVLTCISWPL SELLHYLIGT
   121  LLLLIASIVA ASKSYNQSGL VAGAIFGFMA TFLCMASIWL SYKISCVTQS TDAAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

spleen: 48 nTPM
thymus: 43 nTPM
bone marrow: 41 nTPM
fallopian tube: 36 nTPM
lung: 32 nTPM
breast: 31 nTPM

Single-cell type

kupffer cells: 247 nCPM
hofbauer cells: 225 nCPM
cdc: 220 nCPM
breast secretory cells: 203 nCPM
macrophages: 188 nCPM
pancreatic duct cells: 183 nCPM

Immune cell

classical monocyte: 199 nTPM
intermediate monocyte: 197 nTPM
non-classical monocyte: 174 nTPM
T-reg: 165 nTPM
total PBMC: 113 nTPM
eosinophil: 111 nTPM

Brain region

white matter: 9.7 nTPM
thalamus: 7.4 nTPM
medulla oblongata: 6.3 nTPM
pons: 5.4 nTPM
spinal cord: 5.4 nTPM
choroid plexus: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0.04
gnomAD missense Z: 0.95
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTM7 as an antibody target. Whether an autoantibody or antibody against CMTM7 could matter depends on whether native CMTM7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTM7 is annotated as secreted, so native CMTM7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CMTM7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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