Seroatlas · Human Serome Atlas

CMTM5

CKLF-like MARVEL transmembrane domain-containing protein 5

Also known as: CKLF5_HUMAN, CKLFSF5, FLJ37521

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DZ9
Gene: CMTM5
Ensembl: ENSG00000166091
Chromosome: 14
Canonical length: 223 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q96DZ9|CMTM5
     1  MLSARDRRDR HPEEGVVAEL QGFAVDKAFL TSHKGILLET ELALTLIIFI CFTASISAYM
    61  AAALLEFFIT LAFLFLYATQ YYQRFDRINW PCLLQGHGQS GGPHPLDLLS HSAKVQPQPW
   121  PGLTPPGWHT PAAVPWVPAP APGFWSWLLW FICFHSLGSS DFLRCVSAII IFLVVSFAAV
   181  TSRDGAAIAA FVFGIILVSI FAYDAFKIYR TEMAPGASQG DQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 331 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 331 nTPM
midbrain: 131 nTPM
hippocampal formation: 90 nTPM
basal ganglia: 67 nTPM
amygdala: 63 nTPM
hypothalamus: 56 nTPM

Single-cell type

platelets: 2,685 nCPM
megakaryocytes: 1,570 nCPM
oligodendrocytes: 148 nCPM
megakaryocyte progenitors: 88 nCPM
schwann cells: 83 nCPM
oligodendrocyte progenitor cells: 33 nCPM

Immune cell

total PBMC: 30 nTPM
basophil: 21 nTPM
neutrophil: 4.2 nTPM
plasmacytoid DC: 1 nTPM
eosinophil: 0.9 nTPM
classical monocyte: 0.7 nTPM

Brain region

white matter: 276 nTPM
medulla oblongata: 223 nTPM
cerebellum: 165 nTPM
basal ganglia: 151 nTPM
spinal cord: 142 nTPM
thalamus: 135 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.07
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTM5 as an antibody target. Whether an autoantibody or antibody against CMTM5 could matter depends on whether native CMTM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTM5 is annotated as secreted, so native CMTM5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CMTM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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