Seroatlas · Human Serome Atlas

CMTM3

CKLF-like MARVEL transmembrane domain-containing protein 3

Also known as: BNAS2, CKLF3_HUMAN, CKLFSF3, FLJ31762

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MX0
Gene: CMTM3
Ensembl: ENSG00000140931
Chromosome: 16
Canonical length: 182 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q96MX0|CMTM3
     1  MWPPDPDPDP DPEPAGGSRP GPAVPGLRAL LPARAFLCSL KGRLLLAESG LSFITFICYV
    61  ASSASAFLTA PLLEFLLALY FLFADAMQLN DKWQGLCWPM MDFLRCVTAA LIYFAISITA
   121  IAKYSDGASK AAGVFGFFAT IVFATDFYLI FNDVAKFLKQ GDSADETTAH KTEEENSDSD
   181  SD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

testis: 59 nTPM
adipose tissue: 48 nTPM
placenta: 42 nTPM
cervix: 39 nTPM
ovary: 39 nTPM
spleen: 35 nTPM

Single-cell type

extravillous trophoblasts: 327 nCPM
hofbauer cells: 131 nCPM
megakaryocytes: 118 nCPM
pdcs: 83 nCPM
cdc: 75 nCPM
decidual stromal cells: 69 nCPM

Immune cell

plasmacytoid DC: 25 nTPM
T-reg: 16 nTPM
classical monocyte: 14 nTPM
intermediate monocyte: 14 nTPM
MAIT T-cell: 13 nTPM
myeloid DC: 12 nTPM

Brain region

medulla oblongata: 47 nTPM
white matter: 36 nTPM
thalamus: 35 nTPM
hypothalamus: 32 nTPM
spinal cord: 29 nTPM
pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTM3 as an antibody target. Whether an autoantibody or antibody against CMTM3 could matter depends on whether native CMTM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTM3 is annotated as secreted, so native CMTM3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CMTM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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