Seroatlas · Human Serome Atlas

CMTM2

CKLF-like MARVEL transmembrane domain-containing protein 2

Also known as: CKLF2_HUMAN, CKLFSF2, FLJ25732, MGC39436

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAZ6
Gene: CMTM2
Ensembl: ENSG00000140932
Chromosome: 16
Canonical length: 248 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q8TAZ6|CMTM2
     1  MAPKAAKGAK PEPAPAPPPP GAKPEEDKKD GKEPSDKPQK AVQDHKEPSD KPQKAVQPKH
    61  EVGTRRGCRR YRWELKDSNK EFWLLGHAEI KIRSLGCLIA AMILLSSLTV HPILRLIITM
   121  EISFFSFFIL LYSFAIHRYI PFILWPISDL FNDLIACAFL VGAVVFAVRS RRSMNLHYLL
   181  AVILIGAAGV FAFIDVCLQR NHFRGKKAKK HMLVPPPGKE KGPQQGKGPE PAKPPEPGKP
   241  PGPAKGKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 617 nTPM

Expression across tissuesHPA

Tissue

testis: 617 nTPM
spleen: 1.4 nTPM
cerebellum: 1.3 nTPM
thymus: 1.1 nTPM
bone marrow: 1 nTPM
basal ganglia: 0.9 nTPM

Single-cell type

late primary spermatocytes: 4,322 nCPM
late spermatids: 3,910 nCPM
early spermatids: 3,469 nCPM
neutrophils: 1,006 nCPM
early primary spermatocytes: 126 nCPM
megakaryocytes: 93 nCPM

Immune cell

neutrophil: 1.1 nTPM
total PBMC: 0.8 nTPM
gdT-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 3.9 nTPM
cerebral cortex: 3.7 nTPM
amygdala: 3.5 nTPM
hippocampal formation: 3.3 nTPM
basal ganglia: 2.9 nTPM
white matter: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chemotaxis

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTM2 as an antibody target. Whether an autoantibody or antibody against CMTM2 could matter depends on whether native CMTM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTM2 is annotated as secreted, so native CMTM2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CMTM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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