Seroatlas · Human Serome Atlas

CMTM1

CKLF-like MARVEL transmembrane domain-containing protein 1

Also known as: CKLF1_HUMAN, CKLFH, CKLFH1a, CKLFSF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ96
Gene: CMTM1
Ensembl: ENSG00000089505
Chromosome: 16
Canonical length: 169 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CKLF (chemokine-like factor).[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>Q8IZ96|CMTM1
     1  MDPEHAKPES SEAPSGNLKQ PETAAALSLI LGALACFIIT QANESFITIT SLEICIVVFF
    61  ILIYVLTLHH LLTYLHWPLL DLTNSIITAV FLSVVAILAM QEKKRRHLLY VGGSLCLTAV
   121  IVCCIDAFVV TTKMRTNLKR FLGVEVERKL SPAKDAYPET GPDAPQRPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

testis: 29 nTPM
spleen: 3 nTPM
thymus: 2.5 nTPM
appendix: 2.3 nTPM
cerebellum: 2.2 nTPM
duodenum: 1.9 nTPM

Single-cell type

late spermatids: 198 nCPM
late primary spermatocytes: 78 nCPM
early spermatids: 62 nCPM
microglia: 30 nCPM
oligodendrocyte progenitor cells: 17 nCPM
other brain neurons: 14 nCPM

Immune cell

basophil: 8.8 nTPM
neutrophil: 7.1 nTPM
eosinophil: 6.2 nTPM
classical monocyte: 1.7 nTPM
myeloid DC: 1.6 nTPM
gdT-cell: 1.4 nTPM

Brain region

hypothalamus: 13 nTPM
cerebral cortex: 12 nTPM
medulla oblongata: 12 nTPM
pons: 11 nTPM
white matter: 11 nTPM
cerebellum: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chemotaxis

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTM1 as an antibody target. Whether an autoantibody or antibody against CMTM1 could matter depends on whether native CMTM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTM1 is annotated as secreted, so native CMTM1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CMTM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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