CMKLR2
Chemerin-like receptor 2
Also known as: CML2_HUMAN, GPR1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P46091
- Gene
- CMKLR2
- Ensembl
- ENSG00000183671
- Chromosome
- 2
- Canonical length
- 355 aa
- Protein class
- G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Vesicles,Plasma membrane
OverviewNCBI Gene
Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Predicted to be involved in glucose homeostasis and neuropeptide signaling pathway. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
355 residues, UniProt reviewed canonical sequence.
>P46091|CMKLR2
1 MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV LGIPGNAIVI
61 WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN FHWPFGIWLC KANSFTAQLN
121 MFASVFFLTV ISLDHYIHLI HPVLSHRHRT LKNSLIVIIF IWLLASLIGG PALYFRDTVE
181 FNNHTLCYNN FQKHDPDLTL IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI
241 SSRHFWTILV VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN
301 PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL LETAQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CMKLR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 32 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 32 nTPM
- ovary: 8 nTPM
- placenta: 5.6 nTPM
- vagina: 5.6 nTPM
- cervix: 5.5 nTPM
- skin: 5 nTPM
Single-cell type
- choroid plexus epithelial cells: 237 nCPM
- brain inhibitory neurons: 10 nCPM
- other brain neurons: 6.8 nCPM
- lymphatic endothelial cells: 2.3 nCPM
- brain excitatory neurons: 2.2 nCPM
- ependymal cells: 2.2 nCPM
Immune cell
- basophil: 0.2 nTPM
- naive B-cell: 0.1 nTPM
- neutrophil: 0.1 nTPM
- NK-cell: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- choroid plexus: 36 nTPM
- basal ganglia: 3 nTPM
- hippocampal formation: 3 nTPM
- cerebellum: 2.4 nTPM
- hypothalamus: 2.1 nTPM
- thalamus: 1.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- adipokinetic hormone binding
- adipokinetic hormone receptor activity
- G protein-coupled receptor activity
- neuropeptide binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CMKLR2 as an antibody target. Whether an autoantibody or antibody against CMKLR2 could matter depends on whether native CMKLR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CMKLR2 is annotated at the cell surface, where native CMKLR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CMKLR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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