Seroatlas · Human Serome Atlas

CMKLR1

Chemerin-like receptor 1

Also known as: CML1_HUMAN, RVER1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99788
Gene: CMKLR1
Ensembl: ENSG00000174600
Chromosome: 12
Canonical length: 373 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q99788|CMKLR1
     1  MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV CFLGILGNGL
    61  VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA MDYHWVFGTA MCKISNFLLI
   121  HNMFTSVFLL TIISSDRCIS VLLPVWSQNH RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT
   181  ANLHGKISCF NNFSLSTPGS SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY
   241  LTIVCKLQRN RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL
   301  ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH RSFTKMSSMN
   361  ERTSMNERET GML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMKLR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

spleen: 32 nTPM
blood vessel: 23 nTPM
placenta: 21 nTPM
lymph node: 17 nTPM
smooth muscle: 14 nTPM
lung: 12 nTPM

Single-cell type

kupffer cells: 234 nCPM
macrophages: 105 nCPM
microglia: 98 nCPM
hofbauer cells: 77 nCPM
pdcs: 59 nCPM
monocytes: 34 nCPM

Immune cell

plasmacytoid DC: 18 nTPM
intermediate monocyte: 15 nTPM
gdT-cell: 7.1 nTPM
memory CD8 T-cell: 5.1 nTPM
total PBMC: 5.1 nTPM
classical monocyte: 4.2 nTPM

Brain region

white matter: 16 nTPM
thalamus: 13 nTPM
medulla oblongata: 13 nTPM
pons: 11 nTPM
hypothalamus: 11 nTPM
choroid plexus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0.01
gnomAD missense Z: 0.54
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Formyl peptide receptor-related
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Chemerin-like receptor 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMKLR1 as an antibody target. Whether an autoantibody or antibody against CMKLR1 could matter depends on whether native CMKLR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMKLR1 is annotated at the cell surface, where native CMKLR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CMKLR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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