Seroatlas · Human Serome Atlas

CMIP

C-Maf-inducing protein

Also known as: CMIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY22
Gene: CMIP
Ensembl: ENSG00000153815
Chromosome: 16
Canonical length: 773 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

773 residues, UniProt reviewed canonical sequence.

>Q8IY22|CMIP
     1  MDVTSSSGGG GDPRQIEETK PLLGGDVSAP EGTKMGAVPC RRALLLCNGM RYKLLQEGDI
    61  QVCVIRHPRT FLSKILTSKF LRRWEPHHLT LADNSLASAT PTGYMENSVS YSAIEDVQLL
   121  SWENAPKYCL QLTIPGGTVL LQAANSYLRD QWFHSLQWKK KIYKYKKVLS NPSRWEVVLK
   181  EIRTLVDMAL TSPLQDDSIN QAPLEIVSKL LSENTNLTTQ EHENIIVAIA PLLENNHPPP
   241  DLCEFFCKHC RERPRSMVVI EVFTPVVQRI LKHNMDFGKC PRLRLFTQEY ILALNELNAG
   301  MEVVKKFIQS MHGPTGHCPH PRVLPNLVAV CLAAIYSCYE EFINSRDNSP SLKEIRNGCQ
   361  QPCDRKPTLP LRLLHPSPDL VSQEATLSEA RLKSVVVASS EIHVEVERTS TAKPALTASA
   421  GNDSEPNLID CLMVSPACST MSIELGPQAD RTLGCYVEIL KLLSDYDDWR PSLASLLQPI
   481  PFPKEALAHE KFTKELKYVI QRFAEDPRQE VHSCLLSVRA GKDGWFQLYS PGGVACDDDG
   541  ELFASMVHIL MGSCYKTKKF LLSLAENKLG PCMLLALRGN QTMVEILCLM LEYNIIDNND
   601  TQLQIISTLE STDVGKRMYE QLCDRQRELK ELQRKGGPTR LTLPSKSTDA DLARLLSSGS
   661  FGNLENLSLA FTNVTSACAE HLIKLPSLKQ LNLWSTQFGD AGLRLLSEHL TMLQVLNLCE
   721  TPVTDAGLLA LSSMKSLCSL NMNSTKLSAD TYEDLKAKLP NLKEVDVRYT EAW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 49 nTPM
cerebral cortex: 49 nTPM
small intestine: 46 nTPM
duodenum: 38 nTPM
hypothalamus: 33 nTPM
esophagus: 32 nTPM

Single-cell type

neutrophils: 902 nCPM
platelets: 896 nCPM
urothelial cells: 599 nCPM
lactotrophs: 583 nCPM
salivary basal cells: 582 nCPM
monocytes: 549 nCPM

Immune cell

basophil: 3 nTPM
neutrophil: 2.4 nTPM
eosinophil: 1 nTPM
classical monocyte: 0.7 nTPM
intermediate monocyte: 0.5 nTPM
gdT-cell: 0.4 nTPM

Brain region

hypothalamus: 140 nTPM
cerebral cortex: 133 nTPM
pons: 130 nTPM
basal ganglia: 125 nTPM
hippocampal formation: 122 nTPM
amygdala: 113 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 3.26
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

in utero embryonic development

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat domain superfamily
C-Maf-inducing protein
C-Maf-inducing protein, PH domain
C-Maf-inducing protein PH domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CMIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FLNA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMIP as an antibody target. Whether an autoantibody or antibody against CMIP could matter depends on whether native CMIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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