CMC2
COX assembly mitochondrial protein 2 homolog
Also known as: C16orf61, COXM2_HUMAN, DC13, MGC45036
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NRP2
- Gene
- CMC2
- Ensembl
- ENSG00000103121
- Chromosome
- 16
- Canonical length
- 79 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mitochondria,Cytosol
OverviewNCBI Gene
Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
79 residues, UniProt reviewed canonical sequence.
>Q9NRP2|CMC2
1 MHPDLSPHLH TEECNVLINL LKECHKNHNI LKFFGYCNDV DRELRKCLKN EYVENRTKSR
61 EHGIAMRKKL FNPPEESEKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CMC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 78 nTPM
Expression across tissuesHPA
Tissue
- midbrain: 78 nTPM
- amygdala: 74 nTPM
- spinal cord: 73 nTPM
- cerebral cortex: 72 nTPM
- basal ganglia: 72 nTPM
- hippocampal formation: 68 nTPM
Single-cell type
- late spermatids: 135 nCPM
- oligodendrocytes: 111 nCPM
- brain excitatory neurons: 95 nCPM
- late primary spermatocytes: 93 nCPM
- parietal cells: 88 nCPM
- brain inhibitory neurons: 85 nCPM
Immune cell
- T-reg: 65 nTPM
- plasmacytoid DC: 45 nTPM
- NK-cell: 45 nTPM
- memory B-cell: 39 nTPM
- eosinophil: 37 nTPM
- memory CD4 T-cell: 37 nTPM
Brain region
- white matter: 38 nTPM
- thalamus: 35 nTPM
- hypothalamus: 33 nTPM
- basal ganglia: 30 nTPM
- cerebral cortex: 30 nTPM
- cerebellum: 29 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.54
- gnomAD pLI
- 0.2
- gnomAD missense Z
- -0.65
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CMC2 as an antibody target. Whether an autoantibody or antibody against CMC2 could matter depends on whether native CMC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CMC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CMC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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