Seroatlas · Human Serome Atlas

CMC1

COX assembly mitochondrial protein homolog

Also known as: C3orf68, COXM1_HUMAN, MGC61571

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7K0
Gene: CMC1
Ensembl: ENSG00000187118
Chromosome: 3
Canonical length: 106 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>Q7Z7K0|CMC1
     1  MALDPADQHL RHVEKDVLIP KIMREKAKER CSEQVQDFTK CCKNSGVLMV VKCRKENSAL
    61  KECLTAYYND PAFYEECKME YLKEREEFRK TGIPTKKRLQ KLPTSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 33 nTPM
kidney: 26 nTPM
skeletal muscle: 23 nTPM
liver: 23 nTPM
adrenal gland: 18 nTPM
midbrain: 17 nTPM

Single-cell type

nk-cells: 491 nCPM
late primary spermatocytes: 277 nCPM
megakaryocytes: 223 nCPM
cardiomyocytes: 193 nCPM
innate lymphoid cells: 189 nCPM
t-cells: 179 nCPM

Immune cell

NK-cell: 163 nTPM
memory CD8 T-cell: 70 nTPM
MAIT T-cell: 58 nTPM
naive CD8 T-cell: 42 nTPM
gdT-cell: 40 nTPM
non-classical monocyte: 33 nTPM

Brain region

cerebral cortex: 6.7 nTPM
hypothalamus: 6.2 nTPM
choroid plexus: 5.8 nTPM
cerebellum: 5.6 nTPM
pons: 5.6 nTPM
thalamus: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0.11
gnomAD missense Z: 0.03
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMC1 as an antibody target. Whether an autoantibody or antibody against CMC1 could matter depends on whether native CMC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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