Seroatlas · Human Serome Atlas

CMAS

N-acylneuraminate cytidylyltransferase

Also known as: NEUA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFW8
Gene
CMAS
Ensembl
ENSG00000111726
Chromosome
12
Canonical length
434 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes an enzyme that converts N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc). This process is important in the formation of sialylated glycoprotein and glycolipids. This modification plays a role in cell-cell communications and immune responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q8NFW8|CMAS
     1  MDSVEKGAAT SVSNPRGRPS RGRPPKLQRN SRGGQGRGVE KPPHLAALIL ARGGSKGIPL
    61  KNIKHLAGVP LIGWVLRAAL DSGAFQSVWV STDHDEIENV AKQFGAQVHR RSSEVSKDSS
   121  TSLDAIIEFL NYHNEVDIVG NIQATSPCLH PTDLQKVAEM IREEGYDSVF SVVRRHQFRW
   181  SEIQKGVREV TEPLNLNPAK RPRRQDWDGE LYENGSFYFA KRHLIEMGYL QGGKMAYYEM
   241  RAEHSVDIDV DIDWPIAEQR VLRYGYFGKE KLKEIKLLVC NIDGCLTNGH IYVSGDQKEI
   301  ISYDVKDAIG ISLLKKSGIE VRLISERACS KQTLSSLKLD CKMEVSVSDK LAVVDEWRKE
   361  MGLCWKEVAY LGNEVSDEEC LKRVGLSGAP ADACSTAQKA VGYICKCNGG RGAIREFAEH
   421  ICLLMEKVNN SCQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMAS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 75 nTPM
  • colon: 73 nTPM
  • esophagus: 70 nTPM
  • cerebral cortex: 69 nTPM
  • rectum: 67 nTPM
  • liver: 67 nTPM

Single-cell type

  • esophageal apical cells: 887 nCPM
  • syncytiotrophoblasts: 885 nCPM
  • megakaryocytes: 525 nCPM
  • esophageal suprabasal cells: 235 nCPM
  • cytotrophoblasts: 205 nCPM
  • migrating cytotrophoblasts: 187 nCPM

Immune cell

  • NK-cell: 37 nTPM
  • T-reg: 34 nTPM
  • eosinophil: 32 nTPM
  • myeloid DC: 32 nTPM
  • intermediate monocyte: 30 nTPM
  • non-classical monocyte: 28 nTPM

Brain region

  • midbrain: 80 nTPM
  • hypothalamus: 80 nTPM
  • pons: 80 nTPM
  • cerebral cortex: 65 nTPM
  • basal ganglia: 64 nTPM
  • hippocampal formation: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.56
gnomAD missense Z
2.45
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • N-acylneuraminate cytidylyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMAS as an antibody target. Whether an autoantibody or antibody against CMAS could matter depends on whether native CMAS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMAS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMAS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CMAS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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